CAS · 9008-97-3
Product Overview
Phytohemagglutinins is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Type: | PHA-P |
|---|---|
| Appearance: | Faint brown crystal powder |
| Solubility: | 10 mg/mL, H2O |
| Activity: | 62.5 Ug/mL max |
Applications
1. Immunology and Cell Biology Research
a. T-Cell Mitogen in Lymphocyte Proliferation Assays
Phytohemagglutinins丨CAS 9008-97-3 is a powerful mitogen used to stimulate T lymphocyte proliferation in vitro. It is a standard reagent in:
● Immunocompetence testing
● Lymphocyte transformation tests (LTT)
● Cell-mediated immunity assays
These tests help evaluate immune function in:
● Autoimmune diseases
● Immunodeficiencies (e.g., HIV/AIDS)
● Post-transplant monitoring
b. Cytokine Production Studies
PHA stimulation triggers immune cells to release cytokines (e.g., IL-2, IFN-γ), helping to study:
● Inflammatory responses
● T-cell signaling pathways
● Immunomodulatory drug screening
2. Cancer Research
● PHA is used in tumor immunology to activate lymphocytes and study their response to cancer cells.
● It assists in evaluating anticancer drug efficacy by inducing blastogenesis (cell activation) and proliferation in immune cells.
3. Toxicology and Pharmacology
● PHA's potent biological effects make it useful in studying cellular toxicity, apoptosis, and metabolic responses to compounds.
● It helps model overactivation of immune responses, useful in identifying anti-inflammatory and immunosuppressive drugs.
4. Cytogenetics
● PHA is used to stimulate lymphocyte division for karyotyping (chromosome analysis) in:
- Prenatal screening (e.g., amniocentesis samples)
- Genetic diagnostics
- Chromosomal disorder detection
5. Agriculture and Pest Control Studies
● As a plant lectin with natural insecticidal properties, PHA has been studied in transgenic crops for pest resistance.
● It binds to specific sugar moieties in insect guts, disrupting digestion or development.
Benefits
1. Highly Effective T-Cell Activator
● Phytohemagglutinins丨CAS 9008-97-3 is more potent than many other mitogens (e.g., concanavalin A) at activating T-cells, making it a gold standard for in vitro T-cell function assays.
2. Reliable Tool for Chromosome Studies
● It effectively drives cell cycle entry in non-dividing lymphocytes, enabling large-scale chromosomal studies and cytogenetic analysis.
3. Model for Inflammatory and Immune Pathways
● Because it mimics immune activation, PHA is useful in studying immune regulation, cell signaling, and autoimmune processes.
● It serves as a controlled stimulus in experiments for drug discovery and toxicity testing.
4. Useful in Crop Protection Research
● Its lectin properties are being explored for bioengineering insect-resistant crops, offering an alternative to chemical pesticides.
5. Inexpensive and Readily Available
● PHA is cost-effective and widely used in labs across disciplines from basic immunology to clinical diagnostics.
Conclusion
Phytohemagglutinins丨CAS 9008-97-3 are powerful plant-derived lectins with broad applications in immunology, cytogenetics, cancer research, and agriculture. They are best known as T-cell mitogens in immune function tests and as cell division inducers for chromosome analysis. While toxic in uncooked foods, purified PHA is an essential laboratory tool for understanding immune responses, studying cytokine production, and exploring therapeutic interventions. Its ability to modulate biological systems makes it invaluable in both scientific research and biotechnological innovation.
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