CAS · 98-80-6
Product Overview
Phenylboronic acid is a high-purity catalysts-auxiliary-agent supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | White to off-white solid |
| Purity (HPLC) | 98% min |
| Melting Point | 216–222°C |
Applications
1. Organic Synthesis
✔️ Suzuki–Miyaura Cross-Coupling Reaction
● Phenylboronic acid is best known as a reagent in the Suzuki coupling reaction, where it reacts with aryl or vinyl halides in the presence of a palladium catalyst to form biaryl compounds.
● This reaction is widely used to construct C–C bonds in the pharmaceutical, agrochemical, and materials industries.
✔️ Heck and Sonogashira-type Reactions
● Though primarily associated with Suzuki couplings, it can also participate indirectly in multi-step syntheses involving other cross-coupling reactions.
2. Pharmaceutical Chemistry
✔️ Intermediate for Drug Synthesis
● Phenylboronic acid is an important intermediate in the synthesis of several API scaffolds and drug candidates, particularly in anticancer and antiviral research.
● Its ability to create stable biaryl and heteroaryl linkages is essential for developing bioactive molecules.
3. Biochemical and Biomedical Applications
✔️ Sugar Sensing and Glucose Monitoring
● Boronic acids, including phenylboronic acid, form reversible covalent bonds with diols, especially sugars like glucose.
● This makes phenylboronic acid highly useful in glucose sensors, biosensors, and fluorescent probes for diabetes management and bioimaging.
✔️ Cell Surface and Protein Targeting
● Used in designing molecules that bind selectively to glycoproteins and cell surfaces, phenylboronic acid derivatives can aid in targeted drug delivery and bioconjugation.
4. Polymer and Material Science
✔️ Smart Hydrogels
● Phenylboronic acid丨CAS 98-80-6-containing monomers are used to develop stimuli-responsive hydrogels that swell or contract in response to pH or glucose levels.
● These are being researched for use in drug delivery systems, contact lenses, and tissue engineering.
✔️ Functional Materials
● Incorporated into polymers, resins, and supramolecular assemblies to impart selective binding, electronic tuning, or optical properties.
5. Analytical Chemistry
✔️ Affinity Chromatography
● Phenylboronic acid-functionalized resins are used in affinity chromatography to purify glycoproteins, nucleotides, and carbohydrate-rich compounds from biological mixtures.
✔️ Chemical Probes
● Acts as a chemosensor component for detecting anions, diols, or metal ions, especially in aqueous media.
Benefits
✅ Versatile Reactivity
● The dual nature of boronic acids (nucleophilic boron and electrophilic aromatic ring) provides diverse reactivity for C–C, C–N, and C–O bond formations.
✅ Selective Sugar Binding
● The reversible covalent bonding with cis-diols allows specific and sensitive detection of sugars, making it ideal for biosensing technologies.
✅ Low Toxicity and Good Stability
● Phenylboronic acid is relatively non-toxic and chemically stable under normal laboratory conditions, enabling safe and scalable use.
✅ Water Compatibility
● Unlike many organic reagents, phenylboronic acid shows activity in aqueous conditions, essential for biological and environmental applications.
Conclusion
Phenylboronic acid丨CAS 98-80-6 is a small yet powerful compound with a wide range of applications in organic chemistry, biotechnology, and materials science. Its central role in Suzuki coupling, combined with unique diol-binding capabilities, makes it invaluable in both industrial processes and cutting-edge research. Its multifunctionality ensures it remains a vital reagent in developing future technologies in healthcare, sensing, and smart materials.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.