CAS · 4956-37-0
Product Overview
Oestradiol 17-heptanoate is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White crystalline powder |
|---|---|
| Assay: | 97.0% - 103.0% |
| Identification: | A: IR B: UV C: TLC |
| Melting point: | 94℃ - 114℃ |
| Specific rotation: | +38° to +43° |
| Solubility: | Practically insoluble in water; soluble in alcohol, acetone, dioxane, chloroform; sparingly soluble in vegetable oils. |
| Heptanoic acid: | 0.5% max. |
| Total related substances: | 2.0% max. |
| Any individual impurity: | 0.7% max. |
| Loss on drying: | 0.5% max. |
| Residue on ignition: | 0.1% max. |
| Methanol: | 3000 ppm max. |
| Acetic ether: | 5000 ppm max. |
| Micron: | 100% pass 20 μm |
Applications
1. Pharmaceuticals – Hormone Replacement Therapy (HRT)
Used as a prodrug of estradiol, designed to provide sustained release of active estrogen hormone.
Applied in treatments for:
Menopausal symptoms (hot flashes, osteoporosis prevention)
Hypoestrogenism due to ovarian failure or castration
Certain breast and prostate cancers (as part of hormone therapy)
The esterification at the 17-position prolongs hormone action and reduces dosing frequency.
2. Contraceptive Formulations
Can be incorporated into long-acting contraceptive preparations, such as injectables or implants.
Provides a controlled release of estrogen to maintain hormonal balance.
3. Veterinary Medicine
Used in animals for estrus synchronization and reproductive management.
Improves fertility treatments by modulating hormone levels.
4. Research and Development
Used as a reference compound or standard in pharmacokinetic studies of estrogen esters.
Investigated for its pharmacodynamics and metabolism relative to other estrogen derivatives.
Benefits
1. Prolonged Estrogenic Activity
Ester linkage slows hydrolysis, allowing for extended hormone release and longer half-life compared to free estradiol.
Reduces need for frequent administration, improving patient compliance.
2. Improved Pharmacokinetics
Enhances bioavailability and stability of estradiol.
Allows for formulation into injectable depot preparations or implantable devices.
3. Versatility in Dosage Forms
Suitable for various delivery routes, including:
Intramuscular injections
Subcutaneous implants
Potential transdermal applications
4. Reduced Side Effects
Controlled release leads to more stable plasma hormone levels, which can reduce side effects associated with peak doses.
Conclusion
Oestradiol 17-heptanoate (CAS 4956-37-0) is a long-acting esterified estrogen used primarily in hormone replacement therapies and contraceptive formulations. Its ester moiety prolongs the release and activity of estradiol, improving treatment efficacy and patient adherence. It also finds uses in veterinary medicine and research.
Previous
Next