CAS · 67-20-9
Product Overview
Nitrofurantoin is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | EP9 |
|---|---|
| Appearance: | A yellow crystalline powder |
| Identification: | A. Carry out the test protected from bright light. Use the solution prepared for the assay. Examined between 220nm and 400nm (2.2.25), the solution shows two absorption maxima, at 266nm and 367nm. The ratio of the absorbance at the maximum at 367nm to that at the maximum at 266nm is 1.36 to 1.42. B. Dissolve about 10mg in 10ml of dimethylformamide R. To 1ml of the solution add 0.1ml of 0.5M alcoholic potassium hydroxide. A brown colour develops. |
| Assay: | 98% to 102% |
| Related substance: | 1.0% max |
| Loss on drying: | 1.0% max |
| Sulphated ash: | 0.1% max |
Applications
1. Antibacterial Agent (Primarily Used for Urinary Tract Infections)
Nitrofurantoin丨CAS 67-20-9 is primarily used as an antibiotic for treating urinary tract infections (UTIs):
● Targeted Activity:
It is particularly effective against common UTI-causing bacteria like Escherichia coli, Klebsiella, and Enterococcus. Nitrofurantoin interferes with bacterial enzymes involved in nucleic acid synthesis, protein synthesis, and cell wall formation, thus disrupting bacterial growth.
● First-Line Treatment for UTIs:
It is often used as a first-line treatment for uncomplicated UTIs, especially in women. Nitrofurantoin is generally considered less prone to causing antibiotic resistance compared to other antibiotics.
● Prophylactic Use:
Nitrofurantoin may also be used in chronic UTI prevention to reduce recurrence in patients with frequent infections, especially those with catheters or underlying conditions like diabetes.
2. Pharmacokinetic and Dosage Forms
● Nitrofurantoin is available in various formulations:
Macrobid (Extended-release capsules)
Macrodantin (Immediate-release capsules)
Oral suspension
Tablets
● Action Profile:
Nitrofurantoin has a rapid absorption profile and is mainly excreted in the urine, concentrating in the urinary tract. It is ineffective for infections outside the urinary tract due to its poor tissue penetration.
3. Treatment of Prostate Infections
● In certain cases, nitrofurantoin may be used as part of a regimen to manage prostate infections caused by susceptible bacteria. However, it is generally not the first choice due to its limited effectiveness in the prostate tissue.
4. Veterinary Use
● Livestock and Animal Care:
Nitrofurantoin丨CAS 67-20-9 is also used in veterinary medicine to treat urinary tract infections in animals, particularly for species like cats and dogs, under appropriate veterinary supervision.
Benefits
1. Effective for Lower Urinary Tract Infections
● Nitrofurantoin is particularly well-suited for lower urinary tract infections and has been a mainstay in the treatment of UTIs due to its specificity for these infections and minimal systemic absorption.
2. Minimal Resistance Development
● Compared to other antibiotics used to treat UTIs, nitrofurantoin has a lower tendency for bacterial resistance development, which makes it a favorable option in combating antimicrobial resistance.
3. Fewer Side Effects Compared to Other Antibiotics
● When used for UTIs, nitrofurantoin typically has fewer systemic side effects and is less likely to cause gastrointestinal disturbances compared to broader-spectrum antibiotics like quinolones or penicillins.
4. Prophylactic Use in High-Risk Patients
● It is commonly prescribed to prevent recurring UTIs in patients at higher risk, such as those with recurrent infections, chronic conditions, or urinary catheters.
5. Convenient Dosage Regimens
● With the availability of extended-release formulations (Macrobid), it offers the convenience of once- or twice-daily dosing, which helps with patient compliance, particularly for long-term treatments.
Conclusion
Nitrofurantoin丨CAS 67-20-9 is a highly effective antibiotic primarily used to treat urinary tract infections (UTIs) caused by susceptible bacteria. Its narrow-spectrum activity, low resistance profile, and specificity for urinary tract infections make it an essential drug in the management of UTIs. Nitrofurantoin offers the benefits of minimal systemic side effects, convenient dosing, and prophylactic potential for recurrent infections, though it requires careful monitoring, especially in patients with renal impairment. With its proven efficacy, it continues to be a reliable choice in both clinical and veterinary medicine for managing and preventing UTIs.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.