CAS · 12650-69-0
Product Overview
Mupirocin is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | USP40 |
|---|---|
| Appearance | White or off-white crystalline solid |
| Assay by HPLC (on anhydrous basis) | 920 μg/mg ~ 1020 μg/mg |
| Solubility | Freely soluble in acetone, chloroform, dehydrated alcohol, and methanol; slightly soluble in ether; very slightly soluble in water. |
| Identification (IR) | The IR absorption spectrum of a mineral oil dispersion of it exhibits maxima only at the same wavelengths as that of a similar preparation of Mupiroc in WS. |
| Crystallinity | Particles that do not show birefringence or exhibit extinction position are amorphous; particles that show birefringence and exhibit extinction position are crystalline. |
| Water (K.F.) | 1.0% max. |
| pH (Saturated aqueous solution) | 3.5 ~ 4.5 |
| Residual Solvents Methanol | 3000 ppm max. |
| Ethanol | 5000 ppm max. |
| Acetone | 5000 ppm max. |
| N-Heptane | 5000 ppm max. |
| Ethyl acetate | 5000 ppm max. |
| Propyl ester | 5000 ppm max. |
| Particle size | 100% pass 45 μm |
Applications
Mupirocin is primarily used as a topical antibiotic for the treatment of bacterial skin infections, including impetigo, folliculitis, furunculosis, minor wounds, cuts, and abrasions. It is particularly effective against infections caused by Staphylococcus aureus and Streptococcus pyogenes. In addition to skin applications, Mupirocin is used intranasally to eradicate nasal carriage of S. aureus, including methicillin-resistant strains (MRSA), which helps prevent the spread of infections in healthcare settings and among high-risk patients. Its use extends to pre- and post-surgical prophylaxis to reduce the risk of surgical site infections, as well as in intensive care units to control outbreaks of resistant bacterial strains. Formulated mainly in ointments and creams, Mupirocin allows for targeted treatment of localized infections with minimal systemic exposure.
Benefits
The benefits of Mupirocin include its potent antibacterial activity, particularly against Gram-positive pathogens and resistant strains like MRSA, which makes it highly effective where other antibiotics may fail. Its unique mechanism of action-specifically inhibiting bacterial isoleucyl-tRNA synthetase-prevents bacterial protein synthesis, reducing the likelihood of cross-resistance with other antibiotic classes. Mupirocin is rapidly bactericidal, leading to quick resolution of infections and promoting faster wound healing. Because it is minimally absorbed systemically, it carries a lower risk of systemic side effects and toxicity, making it safe for repeated topical use. Additionally, its efficacy in eradicating nasal carriage of resistant bacteria helps reduce infection transmission in hospitals and community settings, contributing to overall public health.
Conclusion
Mupirocin is an essential topical antibiotic with wide-ranging clinical applications, from treating common skin infections to controlling resistant bacterial strains in healthcare environments. Its combination of targeted efficacy, rapid action, safety, and minimal systemic absorption makes it a reliable option for both patients and healthcare providers. By effectively addressing infections, reducing bacterial carriage, and helping prevent outbreaks of resistant organisms, Mupirocin continues to play a vital role in infection management, wound care, and public health protection.
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