CAS · 78686-79-0
Product Overview
Methyl 5-bromo-2-chloropyridine-3-carboxylate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Off-white solid |
|---|---|
| Purity (HPLC): | 98% min |
| Water: | 0.5% max |
Applications
Methyl 5-bromo-2-chloropyridine-3-carboxylate (CAS 78686-79-0) is a halogenated pyridine derivative widely used as an intermediate in pharmaceutical and agrochemical research. Its structure, containing bromine, chlorine, and a methyl ester on a pyridine ring, makes it highly reactive in cross-coupling reactions, nucleophilic substitutions, and ester transformations. In medicinal chemistry, it is applied to synthesize bioactive pyridine-containing molecules, including enzyme inhibitors, antiviral agents, and other therapeutic compounds. It is also used in agrochemical development for preparing herbicides, fungicides, and insecticides, where halogen substitution enhances stability and potency. Additionally, it serves as a versatile building block in heterocyclic synthesis for advanced materials and fine chemicals.
Benefits
The benefits of methyl 5-bromo-2-chloropyridine-3-carboxylate arise from its multifunctional reactivity and halogenated structure. The bromine atom enables efficient palladium-catalyzed cross-coupling reactions, while the chlorine atom allows selective substitution to diversify molecular structures. The ester functionality provides a handle for hydrolysis, amidation, or reduction reactions, enhancing its versatility in synthesis. Its stability and predictable reactivity make it a reliable intermediate for constructing complex molecules with optimized pharmacological or agrochemical properties. This multifunctionality supports rapid and efficient synthesis, enabling innovation in drug discovery, agrochemical design, and fine chemical research.
Conclusion
Methyl 5-bromo-2-chloropyridine-3-carboxylate is a highly versatile halogenated pyridine intermediate with broad applications in pharmaceuticals, agrochemicals, and heterocyclic synthesis. Its combination of reactive bromine, chlorine, and ester groups allows efficient construction of bioactive and functional molecules. By enabling selective transformations and supporting the creation of diverse chemical derivatives, it continues to play a key role in research, development, and industrial applications.
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