CAS · 619-44-3
Product Overview
Methyl 4-iodobenzoate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White crystal |
|---|---|
| Melting point | 113–117 °C |
| Purity | 99% min |
Applications
Methyl 4-iodobenzoate is a versatile aromatic iodide widely used as an intermediate in organic synthesis, pharmaceuticals, and material science. It serves as a key building block for the preparation of various bioactive molecules, fine chemicals, and advanced organic compounds. The compound is commonly employed in cross-coupling reactions such as Suzuki–Miyaura, Sonogashira, and Heck reactions, where the iodine atom provides high reactivity for carbon–carbon and carbon–heteroatom bond formation. It is also used in the synthesis of dyes, agrochemicals, and functionalized polymers. In medicinal chemistry, methyl 4-iodobenzoate is utilized as a precursor for the design and development of therapeutic agents, enabling selective functionalization and derivatization of aromatic scaffolds.
Benefits
Methyl 4-iodobenzoate offers several advantages due to its high reactivity, chemical stability, and functional versatility. The iodine atom enhances the compound's efficiency in palladium-catalyzed cross-coupling reactions, allowing for rapid and selective formation of complex molecules. Its ester group provides an additional handle for further chemical transformations, including hydrolysis, amidation, or reduction, expanding its utility in multi-step syntheses. The compound is solid, stable under normal storage conditions, and soluble in common organic solvents, facilitating safe handling and incorporation into various synthetic workflows. These properties contribute to high yields, reproducibility, and scalability in both laboratory and industrial applications.
Conclusion
Methyl 4-iodobenzoate is a highly valuable intermediate in organic synthesis, pharmaceuticals, and material chemistry. Its applications in cross-coupling reactions and functionalization, combined with benefits such as reactivity, stability, and versatility, make it an essential building block for constructing complex molecules. The compound continues to play a key role in advanced chemical research, drug development, and fine chemical production.
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