CAS · 175213-46-4
Product Overview
Methyl 1-N-Boc-4-piperidineacetate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colourless liquid |
|---|---|
| Purity (HPLC): | 98% min |
| Optical purity (GC): | 98% min |
| 1H-NMR: | Conforms |
| Water (KF): | 1% max |
Applications
Methyl 1-N-Boc-4-piperidineacetate is an important chemical intermediate extensively used in pharmaceutical and medicinal chemistry. It serves as a building block for the synthesis of piperidine-based drug candidates, including analgesics, antidepressants, and central nervous system (CNS) active compounds. The N-Boc protecting group allows selective reactions at other functional sites while preserving the amine, enabling multi-step synthetic strategies. This compound is also employed in the preparation of heterocyclic derivatives, amides, and esters, which are common scaffolds in the development of bioactive molecules. Its utility extends to combinatorial chemistry and high-throughput synthesis for drug discovery programs.
Benefits
The compound provides several advantages due to its structural features and protecting group strategy. The Boc group protects the nitrogen atom during reactions, allowing selective transformations on the ester or piperidine ring without undesired side reactions. Its methyl ester functionality enhances solubility in organic solvents and facilitates nucleophilic substitution, amidation, or hydrolysis reactions. The compound's stereochemical stability and well-defined structure enable reproducible and high-yield synthesis of downstream intermediates. Additionally, its compatibility with standard laboratory reagents and reaction conditions makes it convenient for both small-scale research and larger-scale pharmaceutical production.
Conclusion
Methyl 1-N-Boc-4-piperidineacetate is a versatile intermediate in pharmaceutical synthesis and medicinal chemistry. Its Boc-protected piperidine structure, chemical stability, and functional flexibility make it an essential building block for developing CNS-active compounds, heterocyclic derivatives, and other bioactive molecules, supporting efficient and selective multi-step synthetic strategies.
Previous
1-(4-Fluorophenyl)piperazine Hydrochloride丨CAS 16141-90-5
Next