CAS · 130209-82-4
Product Overview
Latanoprost is a high-purity prostaglandin supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | Pale yellow to colorless oil |
| Purity (by HPLC) | 94.0% to 102% |
| Identification | HPLC |
| Solubility | Freely soluble in isopropanol and methanol |
| Specific Rotation | +32° to +38° (C=10mg/ml Acetonitrile) |
| Water | 0.5% max. |
| Residue on Ignition | 0.1% max. |
| Heavy Metals | 10ppm max. |
| 15(S)-cis isomer | 0.1% max. |
| 15(S)-trans isomer | 0.1% max. |
| 15(R)-trans isomer | 0.1% max. |
| 15-keto | 0.1% max. |
| Any other impurity | 0.1% max. |
| Total other impurities | 1.0% max. |
| n-Hexane | 0.029% max. |
| Ethanol | 0.5% max. |
| Methanol | 0.3% max. |
| Isopropanol | 0.5% max. |
Applications
1. Treatment of Glaucoma and Ocular Hypertension
● Primary use: Latanoprost丨CAS 130209-82-4 is a first-line medication in the management of open-angle glaucoma, the most common form of glaucoma worldwide. It reduces intraocular pressure, which is the primary modifiable risk factor in glaucoma progression.
● Mechanism of action: It increases the outflow of aqueous humor through the uveoscleral pathway without significantly affecting its production, offering a gentle and effective pressure-lowering effect.
2. Combination Therapy
● Used with other agents: Latanoprost is often combined with beta-blockers (e.g., timolol) or carbonic anhydrase inhibitors for patients who require additional IOP reduction beyond what monotherapy can achieve.
● Fixed-combination products: Commercial formulations combining latanoprost with other agents enhance patient compliance by reducing dosing frequency.
3. Off-Label and Cosmetic Use
● Eyelash enhancement: Due to its effect on hair follicle stimulation, latanoprost and related prostaglandin analogs have been studied and used off-label for eyelash growth (e.g., in alopecia or hypotrichosis).
● Potential for hair regrowth: Investigational studies are exploring latanoprost's ability to stimulate scalp hair growth, although it is not approved for this use.
Benefits
1. Effective Intraocular Pressure Reduction
● Latanoprost丨CAS 130209-82-4 provides consistent and significant reduction in IOP with once-daily dosing, typically lowering pressure by 25–35%.
● Its effect lasts for 24 hours, making it suitable for evening administration and improving compliance.
2. Favorable Safety and Tolerability
● Most patients tolerate latanoprost well, with minimal systemic side effects due to its topical application.
● It does not adversely affect heart rate, blood pressure, or respiratory function, unlike some systemic glaucoma medications.
3. Neuroprotective Potential
● Some studies suggest that prostaglandin analogs like latanoprost may offer neuroprotective benefits to the optic nerve, though this is still under investigation.
4. Convenient Dosing
● Once-daily use (typically at night) promotes adherence to treatment regimens, which is critical for managing chronic conditions like glaucoma.
5. Global Accessibility
● Latanoprost is available as both a brand-name (e.g., Xalatan) and generic product, improving affordability and access to treatment worldwide.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.