CAS · 13433-09-5
Product Overview
L-Aspartyl-L-phenylalanine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to almost white powder |
|---|---|
| Purity (HPLC): | 98% min |
| Water (K.F.): | 2.0% max |
| Carbon: | 53.2~58.2% |
| Nitrogen: | 9.5~10.4% |
| Optical Rotation: | +9.5~+15.5° |
Applications
1.1 Intermediate in the Synthesis of Aspartame
The most significant use of L-Aspartyl-L-phenylalanine is as an intermediate in the production of Aspartame (CAS 22839-47-0), a widely used low-calorie artificial sweetener. Aspartame is formed by methyl esterification of L-Aspartyl-L-phenylalanine.
Aspartame is:
Around 200 times sweeter than sucrose
Used in a variety of dietary and low-calorie food and beverage products
Common in soft drinks, chewing gum, yogurt, sugar-free desserts, and pharmaceuticals
1.2 Research and Development
L-Aspartyl-L-phenylalanine is utilized in peptide chemistry, enzyme studies, and nutritional research as a model compound:
For studying peptide bonding, protease activity, and digestion
As a dipeptide nutrient in cell cultures or biochemical systems
1.3 Pharmaceutical and Nutritional Ingredient Development
Due to its amino acid composition, it has potential as a precursor molecule or building block in:
Peptide drug synthesis
Functional foods and nutraceuticals aimed at controlled nutrient delivery
Benefits
2.1 Key Component in Low-Calorie Sweetener Synthesis
L-Aspartyl-L-phenylalanine enables the industrial-scale production of aspartame, which benefits consumers seeking:
Weight control
Blood sugar regulation
Alternative sweeteners for diabetic-friendly and low-carb diets
2.2 Naturally Derived and Biocompatible
Composed of two natural amino acids:
L-aspartic acid (non-essential)
L-phenylalanine (essential)
This ensures:
Good metabolic compatibility
Biodegradability
Low toxicity
2.3 Useful in Biochemical and Enzymatic Studies
As a small peptide, it is ideal for:
Enzyme-substrate interaction research
Protein folding and peptide mapping investigations
2.4 Customizability for Peptide Modification
Its structure allows:
Selective derivatization (e.g., esterification, amidation)
Use in solid-phase peptide synthesis (SPPS) and drug delivery research
Conclusion
L-Aspartyl-L-phenylalanine (CAS 13433-09-5) is a valuable dipeptide widely recognized as the foundational component in the synthesis of aspartame, one of the world's most commonly used low-calorie sweeteners. Its composition from natural amino acids ensures good safety, biodegradability, and metabolic compatibility, making it suitable for use in food, pharmaceuticals, and nutritional research. In addition to its industrial role, it is also a useful model compound for biochemical and peptide-related studies. As global demand for sugar substitutes and peptide-based innovations grows, L-Aspartyl-L-phenylalanine continues to play a crucial role in health-conscious product development and scientific advancement.
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