Indole-3-carbinol

Indole-3-carbinol is a high-purity pesticide-intermediate supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Nutraceuticals and Dietary Supplements

I3C is widely used as a dietary supplement to promote hormonal balance, especially in women's health.

Often marketed for PMS, menopause symptoms, and estrogen metabolism support.

Can be found in capsules, tablets, or blended with other phytonutrients like DIM (Diindolylmethane).

2. Cancer Prevention and Therapeutics

Chemopreventive agent: I3C is known to modulate phase I and phase II detoxifying enzymes, aiding in the metabolism and elimination of carcinogens.

It induces cell cycle arrest and apoptosis in various cancer cell lines, including breast, prostate, colon, and cervical cancers.

Suppresses tumor growth through pathways such as:

Estrogen receptor modulation

Aryl hydrocarbon receptor activation

NF-κB pathway inhibition

3. Pharmaceutical Research

Used as a lead compound in the design and development of anti-cancer drugs and anti-inflammatory agents.

Investigated in combination therapies to enhance the efficacy of existing cancer treatments.

Studied for its role in immune modulation, oxidative stress reduction, and detoxification mechanisms.

4. Agricultural and Environmental Sciences

Explored as a biomarker for glucosinolate metabolism in plants.

Serves as a reference standard in research into plant-derived anticarcinogens.

✅ Natural Origin

Derived from common vegetables, making it attractive for use in functional foods and natural product-based formulations.

✅ Hormone Regulation

Promotes healthy estrogen metabolism, encouraging the production of beneficial estrogen metabolites like 2-hydroxyestrone over carcinogenic 16α-hydroxyestrone.

✅ Antioxidant and Anti-inflammatory

Reduces oxidative stress and inhibits inflammatory responses, contributing to overall cellular protection and disease prevention.

✅ Wide Therapeutic Potential

Shows promise in a range of conditions: hormone-sensitive cancers, autoimmune disorders, viral infections (e.g., HPV), and detoxification support.

✅ Synergistic Effects

Converts into Diindolylmethane (DIM) under acidic conditions in the stomach, which has complementary health effects.

Indole-3-carbinol (CAS 700-06-1) is a powerful bioactive compound with a broad range of health-promoting and pharmacological properties. It is especially valued for its cancer-preventive, detoxifying, and hormone-regulating effects, making it a key ingredient in dietary supplements, functional foods, and pharmaceutical research. As science continues to uncover its mechanisms, I3C remains a focal point in natural health and medicinal chemistry.

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