CAS · 64603-91-4
Product Overview
Gaboxadol is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off white to straw yellow solid |
|---|---|
| Purity | 98% min |
| Loss on drying | 0.5% max |
Applications
Gaboxadol (CAS 64603-91-4) is a pharmacologically active compound primarily used in neuroscience and pharmaceutical research. It functions as a selective agonist of extrasynaptic GABAA_AA receptors, particularly targeting the δ-subunit-containing receptor subtypes. Its applications include the study of sleep regulation, anxiety, epilepsy, and neurodegenerative disorders due to its ability to modulate tonic inhibitory signaling in the central nervous system. Gaboxadol is also employed in preclinical and clinical research to explore therapeutic interventions for insomnia, cognitive disorders, and mood regulation. Additionally, it serves as a reference compound for the development of novel GABAergic drugs and as a tool in receptor pharmacology studies to elucidate GABAA_AA receptor subtype functions.
Benefits
The benefits of Gaboxadol stem from its selective pharmacological profile and potent modulation of extrasynaptic GABAA_AA receptors. Unlike traditional benzodiazepines, it enhances tonic inhibition without causing widespread sedation or tolerance, making it valuable for studying sleep architecture and neuronal excitability. Its chemical stability and defined stereochemistry facilitate reproducible results in biological assays. Gaboxadol's high specificity allows researchers to differentiate between synaptic and extrasynaptic GABAergic pathways, providing precise mechanistic insights. Furthermore, it is amenable to formulation and experimental design in both in vitro and in vivo studies, supporting a broad range of neuropharmacological investigations.
Conclusion
Gaboxadol is a selective and potent GABAA_AA receptor agonist with significant utility in neuroscience and pharmaceutical research. Its ability to modulate extrasynaptic inhibitory signaling without general sedation makes it an important tool for studying sleep, anxiety, and neurodegenerative processes. By enabling precise exploration of GABAergic mechanisms and supporting the development of targeted therapeutics, Gaboxadol continues to play a critical role in modern neuropharmacology and drug discovery.
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