CAS · 78964-85-9
Product Overview
Fosfomycin tromethamine is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | EP11.0 |
|---|---|
| Appearance | White or almost white hygroscopic powder |
| Assay (Anhydrous Substance) | 98.0%~102.0% |
| Solubility | Very soluble in water, slightly soluble in ethanol (96%) and methanol, practically insoluble in acetone |
| Identification - HPLC | The retention time of the principal peak obtained with the test solution is identical with the reference solution |
| Identification - IR | The infrared absorption spectrum of sample should correspond to that of reference standard |
| pH | 3.5~5.5 |
| Water | 0.5% max |
| Heavy metals | 10 ppm max |
| Phosphates | 500 ppm max |
| Specific optical rotation | -12.5~-13.5° |
| Impurity A | 0.3% max |
| Impurity B | 0.3% max |
| Impurity C | 0.1% max |
| Impurity D | 0.1% max |
| Unspecified impurities | 0.1% max |
| Total Impurities | 0.5% max |
| Ethanol | 5000 ppm max |
| Methanol | 3000 ppm max |
| Total aerobic count | 1000 cfu/g max |
| Mold and yeast | 100 cfu/g max |
| Escherichia coli | Absence |
Applications
Fosfomycin tromethamine is primarily used in pharmaceuticals as a broad-spectrum antibacterial agent. It is applied in the treatment and prevention of urinary tract infections (UTIs), including uncomplicated cystitis, due to its ability to inhibit bacterial cell wall synthesis. The compound is also explored in combination therapy to combat multi-drug resistant bacterial strains. In research, it serves as a reference antibiotic in microbiology studies, antimicrobial susceptibility testing, and the development of new antibacterial formulations. Fosfomycin tromethamine is included in oral dosage forms and other delivery systems designed to provide high bioavailability, and it is also utilized in experimental studies to evaluate pharmacokinetics, bioactivity, and potential synergistic effects with other antimicrobial agents.
Benefits
The benefits of Fosfomycin tromethamine derive from its broad-spectrum antibacterial activity, stability, and favorable pharmacokinetic profile. It is effective against a wide range of Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics, which makes it a valuable option in challenging infections. Its tromethamine salt form enhances solubility and absorption, allowing convenient oral administration and improved bioavailability. The compound's single-dose efficacy for certain urinary tract infections reduces treatment complexity and improves patient compliance. Additionally, its unique mechanism of action-targeting early-stage bacterial cell wall synthesis-minimizes cross-resistance with other antibiotic classes, supporting its use in multidrug-resistant infections and combination therapy strategies.
Conclusion
Fosfomycin tromethamine is a versatile antibacterial agent widely used for treating urinary tract infections and in antimicrobial research. Its broad-spectrum activity, oral bioavailability, and unique mechanism of action make it effective against resistant bacterial strains and suitable for both clinical and experimental applications. These characteristics ensure its continued relevance in pharmaceutical development, infection management, and microbiological studies.
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