CAS · 136399-06-9
Product Overview
Fmoc-N-amido-PEG24-acid is a high-purity polyethylene-glycol supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Yellow liquid |
|---|---|
| Purity | 98% min |
| Homologue impurity | 0.5% max |
Applications
Fmoc-N-amido-PEG24-acid is primarily used in peptide synthesis and bioconjugation applications. The compound features a polyethylene glycol (PEG) chain linked to a carboxylic acid and protected by an Fmoc group, making it suitable as a spacer or linker in the synthesis of PEGylated peptides, proteins, and other biologically active molecules. It is widely applied in pharmaceutical research to improve the solubility, stability, and pharmacokinetic properties of therapeutic peptides or proteins. Additionally, it is employed in drug delivery systems, antibody-drug conjugates (ADCs), and surface modification of biomaterials, where PEGylation helps reduce immunogenicity and enhance circulation time in vivo. The Fmoc protection allows for precise incorporation into solid-phase synthesis protocols, enabling controlled assembly of complex biomolecules.
Benefits
The primary benefits of Fmoc-N-amido-PEG24-acid lie in its ability to improve the physicochemical and biological properties of biomolecules. The PEG24 chain provides enhanced water solubility, reduces aggregation, and prolongs systemic circulation, which is particularly important for therapeutic peptides and proteins. The Fmoc protecting group ensures selective reactions at the carboxyl terminus during peptide synthesis, allowing for high coupling efficiency and minimized side reactions. Its chemical stability and well-defined structure facilitate reproducible incorporation into peptides and conjugates, ultimately enabling the production of high-purity, functionally optimized molecules for research and drug development.
Conclusion
Fmoc-N-amido-PEG24-acid is a highly valuable reagent in modern peptide chemistry and bioconjugation. Its combination of a PEG24 spacer, carboxyl functionality, and Fmoc protection allows for precise, efficient, and reproducible synthesis of PEGylated biomolecules with improved solubility, stability, and pharmacokinetics. By streamlining the modification of peptides, proteins, and other biologically active molecules, it supports the development of advanced therapeutics, drug delivery systems, and functional biomaterials.
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