CAS · 71989-28-1
Product Overview
Fmoc-L-Methionine is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White powder |
|---|---|
| Purity (HPLC) | 99.0% min |
| Water (KF) | 1.0% max |
Applications
Fmoc-L-Methionine is a protected amino acid widely used in peptide synthesis and protein engineering. Its Fmoc (9-fluorenylmethyloxycarbonyl) protective group enables selective and stepwise assembly of peptides using solid-phase peptide synthesis (SPPS), making it essential for the construction of complex peptide sequences. It is particularly employed in the production of therapeutic peptides, peptide-based vaccines, and bioactive compounds in pharmaceutical research. Additionally, Fmoc-L-Methionine is utilized in biochemical and structural studies to investigate protein folding, enzyme mechanisms, and receptor-ligand interactions. Its compatibility with automated peptide synthesizers and high efficiency in protecting the amino group make it a preferred reagent in both laboratory-scale research and commercial peptide manufacturing.
Benefits
The key benefits of Fmoc-L-Methionine stem from its protective functionality and chemical stability. The Fmoc group allows for controlled, selective deprotection under mild conditions, minimizing side reactions and preserving the integrity of sensitive peptide sequences. Methionine itself introduces a sulfur-containing residue into peptides, which can contribute to structural stability, redox activity, and biological functionality. Fmoc-L-Methionine improves synthetic efficiency by enabling high-purity peptide assembly and is compatible with a wide range of coupling reagents and solvents used in SPPS. Its use supports reproducible peptide synthesis, reduces purification requirements, and facilitates large-scale production of peptides for pharmaceutical, diagnostic, and research applications.
Conclusion
In summary, Fmoc-L-Methionine is a crucial protected amino acid for peptide synthesis and protein research. Its applications include therapeutic peptide production, structural biology studies, and bioactive molecule development, while its benefits encompass selective protection, chemical stability, synthetic efficiency, and compatibility with automated peptide synthesis. By combining functional versatility with reliability, Fmoc-L-Methionine continues to play an essential role in advancing peptide chemistry and pharmaceutical research.
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