CAS · 924-44-7
Product Overview
Ethyl glyoxalate is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colorless or light yellow liquid |
|---|---|
| Purity (GC): | 97.0% min |
| Content (w/w): | 50% min in toluene |
Applications
1. Pharmaceutical Intermediates
Ethyl glyoxalate is a valuable building block in pharmaceutical chemistry due to its dual functionality (aldehyde and ester). It is widely used for:
● Synthesis of heterocyclic compounds such as:
Pyrazoles
Pyrroles
Oxazoles
Isoxazoles
These are core structures in many antibacterial, anti-inflammatory, antiviral, and anticancer agents.
● Asymmetric synthesis:
Its reactivity enables chiral auxiliaries or catalysts to produce enantiomerically enriched intermediates, particularly in natural product synthesis.
2. Agrochemical Development
● Serves as an intermediate in the synthesis of herbicides, fungicides, and insecticides.
● Useful for creating bioactive heterocycles that target plant or pest enzyme systems.
3. Flavor and Fragrance Industry
● Although not used directly in flavors, ethyl glyoxalate may be used in fine chemical synthesis to create aroma compounds and functionalized esters.
● Its aldehyde functionality enables selective reactions for flavor precursors and perfume ingredients.
4. Organic Synthesis & Research
● Versatile synthon in:
Aldol-type condensations
Michael additions
Reductive aminations
Multicomponent reactions (MCRs)
● Ethyl glyoxalate丨CAS 924-44-7 is especially valued in the construction of α-keto esters and α-hydroxy acids.
● Widely used in:
Academic research
Method development in organocatalysis
Green chemistry experiments with atom-efficient reactions
5. Polymer and Material Chemistry (Niche)
● Can be used to introduce reactive aldehyde functionality into polymer backbones or side chains, particularly for biodegradable or functionalized resins.
Benefits
1. Bifunctional Reactivity
● Contains both aldehyde and ester groups, enabling sequential or tandem reactions in one-pot syntheses.
● Ideal for complex molecule construction with minimal protection/deprotection steps.
2. High Versatility
● Participates in a wide range of nucleophilic addition, cyclization, and reduction reactions.
● Supports tailored synthesis of custom compounds in pharmaceuticals and agrochemicals.
3. Efficient Building Block
● Excellent for atom-economical synthesis, making it attractive for green chemistry and process development.
● Forms stable intermediates and helps reduce reaction steps in large-scale applications.
4. Scalability and Availability
● Commercially available in bulk quantities and adaptable for industrial processes with controlled handling.
● Often used in flow chemistry or automated platforms for reaction screening.
Conclusion
Ethyl glyoxalate丨CAS 924-44-7 is a highly useful synthetic intermediate prized for its reactive aldehyde and ester functionalities. It plays a critical role in the development of pharmaceuticals, agrochemicals, and heterocyclic compounds, while also proving valuable in academic and industrial synthesis. Its versatility, combined with relatively straightforward handling, makes it a key component in modern organic chemistry and applied research.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.