CAS · 921-26-6
Product Overview
Dichloro N,N-Diisopropylphosphoramidite is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colorless to light yellow Liquid |
|---|---|
| Purity: | 98.0% min |
Applications
Dichloro N,N-Diisopropylphosphoramidite is a reactive phosphorus-containing compound primarily used as an intermediate in organic synthesis and nucleotide chemistry. It is widely employed in the synthesis of phosphoramidite derivatives for oligonucleotide and DNA/RNA synthesis, enabling the formation of phosphite linkages that are later oxidized to stable phosphate backbones. In addition, it is utilized in the preparation of various phosphorus-containing ligands, agrochemicals, and organophosphorus compounds for medicinal and materials chemistry. Its high reactivity toward nucleophiles makes it a versatile reagent for coupling reactions, derivatization, and as a building block in the development of specialty phosphoramidites and functionalized phosphorous intermediates.
Benefits
The compound offers excellent chemical reactivity and selectivity due to the presence of reactive dichloro and phosphoramidite groups, allowing efficient and controlled synthesis of phosphite derivatives. Its structure ensures compatibility with a wide range of alcohols and nucleophilic substrates, facilitating high-yielding transformations in multistep synthetic pathways. Dichloro N,N-Diisopropylphosphoramidite is also stable under proper storage conditions and soluble in common organic solvents, making it convenient for laboratory and industrial use. Its versatility and reliability enable precise control over stereochemistry and functionalization, which is critical in nucleotide synthesis and organophosphorus chemistry.
Conclusion
Dichloro N,N-Diisopropylphosphoramidite is a valuable intermediate in nucleotide synthesis, organophosphorus chemistry, and fine chemical research. Its reactive dichloro-phosphoramidite functionality, chemical stability, and compatibility with various nucleophiles make it essential for the efficient preparation of phosphoramidite derivatives, ligands, and specialty phosphorus-containing compounds.
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