CAS · 960404-48-2
Product Overview
Dapagliflozin Propanediol is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to off-white powder |
|---|---|
| Melting point: | 72-80 °C |
| Optical rotation: | +13° ~ +17° |
Applications
1. Treatment of Type 2 Diabetes Mellitus
Primary application is as an oral anti-diabetic agent.
Inhibits SGLT2 in the proximal renal tubules, reducing reabsorption of glucose and promoting urinary glucose excretion.
Effective as monotherapy or in combination with other drugs like metformin, insulin, or DPP-4 inhibitors.
2. Heart Failure and Chronic Kidney Disease (CKD)
Dapagliflozin has been shown to reduce the risk of cardiovascular death and hospitalization for heart failure, regardless of diabetes status.
Demonstrated renal protective effects, slowing progression of chronic kidney disease.
Approved for use in HFrEF (heart failure with reduced ejection fraction) and CKD patients.
3. Weight Loss and Blood Pressure Reduction
Provides modest weight loss due to caloric loss via glucosuria.
Exhibits mild diuretic effects, helping lower systolic and diastolic blood pressure.
Benefits
Effective glucose lowering without causing hypoglycemia (when used alone).
Reduces cardiovascular risk and provides renal protection.
Improves glycemic control, aids in weight loss, and helps in blood pressure management.
Favorable oral bioavailability and well-tolerated in long-term use.
Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.