CAS · 96946-42-8
Product Overview
Cisatracurium besylate is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Grade | USP43 |
| Appearance | White to off-white powder, odorless. Hygroscopic |
| Identification | A. HPLC, B. IR |
| Assay | 97.0% to 102.0% |
| Residue on ignition | 0.1% max |
| Organic impurities | cis-Quaternary acid: 0.2% max |
| (R)-N-Methyllaudanosine: 0.2% max | |
| (R)-Laudanosine: 0.6% max | |
| cis-Quaternary methyl ester: 0.4% max | |
| cis-Quaternary alcohol: 0.5% max | |
| R-trans-R-trans-Atracurium: 0.2% max | |
| R-cis-R-trans-Atracurium: 0.8% max | |
| trans-Monoquaternary compound: 0.5% max | |
| trans-Monoacrylate: 0.5% max | |
| cis-Monoquaternary compound: 0.7% max | |
| cis-cis-Triester analog: 0.4% max | |
| cis-Monoacrylate: 1.0% max | |
| Any individual unspecified impurity | 0.1% max |
| Total impurities | 3.0% max |
| Limit of methyl benzenesulfonate | 10 ppm max |
| Optical Rotation | -60.0° to -54.0° |
| Water Determination | 5.0% max |
| Residual solvents | Methanol: 3000 ppm max |
| Acetone: 5000 ppm max | |
| Diethyl ether: 5000 ppm max | |
| Methylene chloride: 600 ppm max | |
| Acetonitrile: 410 ppm max | |
| Ethyl acetate: 5000 ppm max | |
| Toluene: 890 ppm max |
Applications
1. Anesthesia During Surgery
Cisatracurium besylate丨CAS 96946-42-8 is primarily used as part of general anesthesia to induce muscle relaxation during surgical procedures.
● Facilitates endotracheal intubation: By relaxing the muscles of the airway, it makes it easier to insert an endotracheal tube.
● Muscle relaxation: Provides muscle paralysis during surgery, helping to avoid involuntary movements and making surgical procedures more precise.
2. Intensive Care Unit (ICU) for Ventilation
In ICU settings, cisatracurium besylate is used to facilitate mechanical ventilation for patients who need neuromuscular blockade for long-term sedation or in cases of acute respiratory distress syndrome (ARDS).
● Continuous neuromuscular blockade: Useful in critically ill patients who are mechanically ventilated and need muscle relaxation for an extended period.
3. Induction of Controlled Hypotension
Cisatracurium can be employed during controlled hypotension procedures, where it helps reduce muscle tone and improves surgical access, especially in delicate surgeries like spinal surgeries or brain surgery.
Benefits
1. Favorable Pharmacokinetic Properties
Compared to other neuromuscular blockers, cisatracurium besylate has:
● Minimal histamine release, which reduces side effects like hypotension or bronchospasm seen with other agents like atracurium.
● Non-organ dependent elimination: It undergoes spontaneous degradation at physiological pH and temperature, primarily through Hofmann elimination, making it useful for patients with renal or hepatic insufficiency.
2. Faster Onset and Controlled Duration of Action
Cisatracurium besylate丨CAS 96946-42-8 offers a rapid onset of action, typically within 2-3 minutes of intravenous administration. It also provides controlled duration, which is useful for procedures of varying lengths.
● Reversible: Its effects can be reversed with acetylcholinesterase inhibitors (e.g., neostigmine) if required.
3. Reduced Risk of Side Effects
As a cis isomer, cisatracurium has a lower risk of side effects such as tachycardia or hypotension compared to the trans isomer (atracurium).
● Less cardiovascular effect: Unlike some other neuromuscular blockers, it has a lower likelihood of causing undesirable cardiovascular effects, making it safer for use in patients with cardiovascular conditions.
4. Well-Suited for Long-Term Use in ICU
Given its short-to-medium duration of action, cisatracurium is ideal for long-term sedation in ICU patients requiring neuromuscular blockade for extended mechanical ventilation.
Precautions and Considerations
● Dosage adjustments may be necessary for patients with severe liver dysfunction or prolonged hypothermia.
● Monitoring of neuromuscular function is important during its use to prevent over or under-paralysis.
● Allergic reactions, although rare, should be monitored, especially if the patient has a known history of sensitivity to neuromuscular blocking agents.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.