CAS · 310454-53-6
Product Overview
Cbz-Piperidine-3-carboxylic acid ethyl ester is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Light yellow liquid |
|---|---|
| Assay (GC): | 98% min |
Applications
Cbz-Piperidine-3-carboxylic acid ethyl ester is a protected amino acid derivative widely used in peptide synthesis, pharmaceutical research, and organic chemistry. The carbobenzyloxy (Cbz) protecting group safeguards the amine functionality, allowing for selective reactions at other positions, while the ethyl ester provides a reactive site for further modification. This compound serves as a key intermediate in the synthesis of piperidine-containing peptides, heterocyclic drugs, and bioactive molecules. It is also utilized in medicinal chemistry to develop enzyme inhibitors, receptor modulators, and other pharmacologically relevant compounds. Additionally, Cbz-Piperidine-3-carboxylic acid ethyl ester is applied in combinatorial chemistry and structure-activity relationship studies to optimize drug candidates.
Benefits
The Cbz protection and ethyl ester functionalization provide significant advantages in multi-step synthesis. The Cbz group ensures the amine remains inert under standard reaction conditions, allowing selective transformations on the carboxylate or piperidine ring. The ester group is readily hydrolyzable or convertible to amides, making it highly versatile for downstream modifications. The compound exhibits good chemical stability, solubility in organic solvents, and compatibility with both solution-phase and solid-phase peptide synthesis methods. Its use allows for high-yield reactions, enantiomeric purity retention, and efficient preparation of complex molecules with controlled stereochemistry.
Conclusion
Cbz-Piperidine-3-carboxylic acid ethyl ester is an essential protected amino acid intermediate in pharmaceutical and peptide synthesis. Its Cbz-protected amine and ester functionality provide stability, selectivity, and versatility, enabling the efficient construction of piperidine-based bioactive compounds. This compound continues to support drug discovery, peptide research, and advanced organic synthesis by facilitating high-precision, multi-step chemical transformations.
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