CAS · 151533-22-1
Product Overview
Calcium levomefolate is a high-purity nutrient-additives supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | USP40 |
|---|---|
| Appearance | White to light yellowish powder |
| Identification | Infrared absorption Tests for Calcium Retention time of the principal peak in HPLC conforms with that of the standard |
| Calcium (dry basis) | 7.0% – 8.5% |
| Water | 6.0% – 17.0% |
| Heavy metals | 20 ppm max |
| Elemental impurities – Chloride | 0.5% max |
| Elemental impurities – Boron | 50 µg/g max |
| Elemental impurities – Platinum | 10 µg/g max |
| Elemental impurities – Arsenic | 1.5 µg/g max |
| Elemental impurities – Lead | 1.0 µg/g max |
| Elemental impurities – Mercury | 1.5 µg/g max |
| D-5-Methylfolate | 1.0% max |
| Residual solvents – Ethanol | 5,000 ppm max |
| Residual solvents – 2-Propanol | 5,000 ppm max |
| Related substances – Impurity A | 0.5% max |
| Related substances – Impurity B | 1.0% max |
| Related substances – Impurity C | 1.0% max |
| Related substances – Impurity D | 0.5% max |
| Related substances – Impurity E | 0.5% max |
| Related substances – Impurity F | 0.5% max |
| Related substances – Impurity G | 0.5% max |
| Related substances – Impurity H | 0.5% max |
| Related substances – Impurity I | 0.5% max |
| Related substances – Impurity J | 0.15% max |
| Total impurities | 2.5% max |
| Assay (anhydrous basis) | 95.0% – 102.0% |
| Total plate count | 1,000 CFU/g max |
| Yeast & mold | 100 CFU/g max |
| Salmonella | Conforms |
| Escherichia coli | Conforms |
| Staphylococcus aureus | Conforms |
| Pseudomonas aeruginosa | Conforms |
| Candida albicans | Conforms |
| Clostridia | Conforms |
Applications
Calcium levomefolate is the calcium salt of L-5-methyltetrahydrofolate, the biologically active form of folate used directly by the body. It is widely applied in pharmaceutical and nutraceutical formulations to prevent and treat folate deficiency, particularly in individuals with impaired folic acid metabolism. In clinical nutrition, it is included in prenatal supplements to support normal fetal development and reduce the risk of neural tube defects. Calcium levomefolate is also used in adjunct therapy for certain neurological, cardiovascular, and psychiatric conditions where folate metabolism plays a critical role. Additionally, it is incorporated into fortified foods and medical nutrition products requiring a stable and bioactive folate source.
Benefits
Calcium levomefolate offers significant advantages due to its high bioavailability and direct biological activity. Unlike folic acid, it does not require enzymatic conversion, making it especially suitable for individuals with genetic variations affecting folate metabolism. The compound supports DNA synthesis, amino acid metabolism, and methylation processes essential for cell division and neurological function. Its calcium salt form provides good stability, solubility, and compatibility with a wide range of formulations. Calcium levomefolate is well tolerated and effective at lower doses, ensuring consistent physiological benefits in nutritional and therapeutic applications.
Conclusion
Calcium levomefolate is a highly effective and biologically active folate source with broad applications in pharmaceuticals, nutrition, and fortified products. Its benefits, including superior bioavailability, metabolic readiness, stability, and suitability for sensitive populations, make it an essential ingredient for supporting maternal health, cellular function, and overall metabolic balance. Continued use of calcium levomefolate contributes to advanced nutritional solutions and improved clinical outcomes.
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