CAS · 4165-57-5
Product Overview
Bromobenzene-D5丨4165-57-5 is a deuterated form of bromobenzene where all five hydrogen atoms in the benzene ring are replaced with deuterium (D). This compound is widely used in scientific and industrial applications due to its stable isotopic nature and unique chemical properties.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | Colorless liquid |
| Deuteration Rate | 99% min |
| Purity | 99.0% min |
Applications
1. Analytical Chemistry & Spectroscopy
Nuclear Magnetic Resonance (NMR) Studies:
Bromobenzene-D5丨4165-57-5 is commonly used as a solvent or reference standard in ¹H NMR and ²H NMR spectroscopy due to the replacement of hydrogen with deuterium, which minimizes background proton signals.
Useful in calibrating deuterium chemical shifts in analytical instruments.
Mass Spectrometry (MS) Standards:
Used as an internal standard for isotope dilution mass spectrometry (IDMS), enhancing the accuracy of quantitative analysis.
Gas Chromatography (GC) & Liquid Chromatography (LC):
Acts as an internal standard for environmental monitoring, pharmaceutical quality control, and forensic analysis.
2. Pharmaceutical & Biomedical Research
Metabolic and Drug Distribution Studies:
Used in the investigation of drug metabolism and pharmacokinetics (DMPK), as it allows tracing molecular pathways without interfering with biological systems.
Tracer in Isotopic Labeling Studies:
Its deuterium-labeled structure makes it useful for studying biochemical reactions and metabolic pathways, especially in pharmaceutical development.
3. Organic Synthesis & Chemical Reactions
Precursor in Synthesis of Deuterated Compounds:
Used in synthesizing other deuterium-labeled aromatic compounds, which are critical for medicinal chemistry and materials science.
Grignard Reagent Formation:
Serves as a precursor in organometallic chemistry, particularly for forming Grignard reagents (C₆D₅MgBr) used in carbon-carbon bond formation reactions.
4. Environmental and Forensic Analysis
Environmental Pollutant Studies:
Used in research to track the behavior of brominated organic compounds in the environment.
Forensic Toxicology:
Helps in the identification of illicit substances and contaminants using isotope ratio mass spectrometry (IRMS).
Benefits
1. Enhanced Analytical Precision
● The presence of deuterium reduces interference in spectroscopic and chromatographic analyses, improving signal clarity and accuracy.
2. High Stability and Low Reactivity
● The C-D bonds in Bromobenzene-D5丨4165-57-5 are stronger than C-H bonds, making it more resistant to degradation and ideal for long-term studies.
3. Facilitates Accurate Metabolic and Drug Research
● Used as a non-radioactive tracer, it allows scientists to track molecular interactions safely and efficiently.
4. Improves Yield and Efficiency in Organic Synthesis
● Acts as a key building block in advanced pharmaceutical synthesis, ensuring consistency in drug development.
5. Environmental and Forensic Advantages
● Essential for pollution monitoring and forensic investigations, providing reliable isotope-labeled references.
Conclusion
Bromobenzene-D5丨4165-57-5 is a crucial compound in analytical chemistry, pharmaceutical research, organic synthesis, and forensic science. Its isotopic labeling properties enhance analytical accuracy, making it a valuable tool in various scientific and industrial applications.
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