Boc-L-Hydroxyproline

Boc-L-Hydroxyproline is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

Boc-L-Hydroxyproline (CAS 13726-69-7) is a protected amino acid widely used as an intermediate in peptide synthesis and pharmaceutical research. The tert-butoxycarbonyl (Boc) group serves as an effective N-terminal protecting group, enabling controlled stepwise peptide assembly under mild conditions. Boc-L-Hydroxyproline is commonly employed in the synthesis of bioactive peptides, peptidomimetics, and collagen-related sequences where hydroxyproline is essential for conformational stability. In medicinal chemistry, it is used to build intermediates for drug candidates targeting fibrosis, inflammation, oncology, and metabolic disorders. The compound is also applied in the development of cosmetic peptides and biomaterials, particularly those designed to mimic or support extracellular matrix structures. In addition, Boc-L-Hydroxyproline is utilized in academic research and process development as a reference or starting material for stereochemically defined proline derivatives.

The main benefits of Boc-L-Hydroxyproline arise from its high stereochemical purity, structural relevance, and synthetic convenience. The Boc protecting group provides excellent stability during peptide coupling reactions while being easily removed under acidic conditions without affecting the hydroxy functionality. The presence of the hydroxyl group on the proline ring enhances hydrogen bonding and conformational control, which is critical for designing peptides with defined secondary structures. Using Boc-L-Hydroxyproline allows chemists to efficiently introduce hydroxyproline residues with precise configuration, improving reproducibility and yield in peptide synthesis. From a manufacturing perspective, it supports scalable and well-established synthetic protocols, making it suitable for both research-scale and industrial-scale applications. Its compatibility with standard coupling reagents and solid-phase peptide synthesis further increases its versatility and cost-effectiveness.

Boc-L-Hydroxyproline is a valuable protected amino acid that plays an important role in peptide synthesis, pharmaceutical development, and biomaterial research. Its combination of reliable N-protection, preserved stereochemistry, and functional hydroxyl group enables the efficient construction of complex and biologically relevant peptides. As demand continues to grow for peptide-based therapeutics, cosmetic actives, and advanced biomaterials, Boc-L-Hydroxyproline will remain a key building block supporting precision, efficiency, and innovation in modern chemical and life science industries.

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