CAS · 491-67-8
Product Overview
Baicalein is a high-purity plant-extracts-natural-products supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Fine powder |
|---|---|
| Assay (Baicalein) | 98.0% max (HPLC) |
| Color | Yellow |
| Odor | Characteristic |
| Taste | Characteristic |
| Mesh size/Sieve | 95% min pass 80 mesh |
| Bulk density | 0.8 g/ml max |
| Loss on Drying | 5.0% max |
| Residue on Ignition | 2.0% max |
| Identifiable active ingredient | Complies with standards |
| Pesticide Residues | USP<561> |
| Solvent Residues | USP<467> |
| Heavy Metals | 10 ppm max |
| Lead | 2 ppm max |
| Arsenic | 1 ppm max |
| Mercury | 0.1 ppm max |
| Cadmium | 1 ppm max |
| Total Plate Count | 1000 cfu/g max |
| Yeast & Mold | 100 cfu/g max |
| E. Coli | Negative |
| Salmonella | Negative |
| Staphylococcus | Negative |
Applications
1. Pharmaceutical and Medicinal Research
Baicalein丨CAS 491-67-8 is extensively studied for its pharmacological properties, particularly in the areas of:
● Anti-inflammatory activity: Inhibits COX-2 and iNOS expression, reducing inflammation in various models (arthritis, colitis, etc.).
● Antioxidant effects: Scavenges free radicals and upregulates antioxidant enzymes like SOD and catalase.
● Anticancer potential: Shown to inhibit proliferation and induce apoptosis in several cancer cell lines (e.g., breast, liver, lung, prostate).
● Neuroprotection: Demonstrated protective effects against neurodegenerative conditions such as Alzheimer's, Parkinson's, and cerebral ischemia by modulating oxidative stress and apoptosis.
● Antiviral and antimicrobial activity: Active against viruses such as dengue, influenza, and hepatitis B; also inhibits bacterial biofilms.
2. Nutraceuticals and Dietary Supplements
● Included in formulations for cognitive health, immune support, and inflammation reduction.
● Often combined with other flavonoids or herbal extracts to enhance synergistic health benefits.
● Studied in the context of age-related diseases, including metabolic syndrome and cognitive decline.
3. Cosmetics and Skincare
● Used in skincare formulations for its anti-aging, antioxidant, and skin-soothing properties.
● Helps protect skin from UV-induced oxidative damage, potentially reducing wrinkles and hyperpigmentation.
● Anti-inflammatory action also makes it suitable for sensitive or acne-prone skin.
4. Cardiovascular and Metabolic Health
● Shown to reduce LDL oxidation, prevent endothelial dysfunction, and suppress vascular inflammation.
● May assist in controlling hyperglycemia and insulin resistance, making it of interest in type 2 diabetes management.
Benefits
1. Multifunctional Bioactivity
● Baicalein丨CAS 491-67-8 offers a broad spectrum of pharmacological effects, making it a promising lead compound for drug discovery and natural product-based therapy.
2. Natural Origin
● Derived from Scutellaria baicalensis, it aligns with traditional herbal medicine practices and modern phytotherapy.
3. Synergistic Compatibility
● Can be combined with other flavonoids (e.g., baicalin, wogonin) or drugs to enhance efficacy or reduce toxicity.
4. Low Toxicity Profile
● Generally regarded as safe in moderate doses, with low cytotoxicity to normal cells while being selectively active against diseased cells.
Conclusion
Baicalein丨CAS 491-67-8 is a potent bioactive flavonoid with promising applications in pharmaceuticals, nutraceuticals, and cosmetics. Its diverse therapeutic effects-including antioxidant, anti-inflammatory, anticancer, and neuroprotective actions-make it a valuable compound for both traditional medicine and modern drug development. As research continues to evolve, baicalein is expected to play a key role in natural and functional product innovation.
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