CAS · 313-67-7
Product Overview
Aristolochic acid, with the Chemical Abstracts Service (CAS) number 313-67-7, is a naturally occurring compound found in plants of the Aristolochia and Asarum genera. It is a nitrophenanthrene carboxylic acid and is known for its toxic and carcinogenic properties. Despite its historical use in traditional medicine, aristolochic acid is now recognized as a significant health hazard and is heavily regulated or banned in many countries.
Product Specifications
| Property | Specification |
|---|---|
| HPLC Purity | 98.0% min |
| Appearance | Orange powder |
| Storage | 2-8℃, Sealing and avoiding light |
| Remarks | Namely with the use |
| Use | Recommended for qualitative control and pharmacological research. Quantitative, standard testing, and use of pharmaceutical raw materials are not recommended. |
Applications
1. Traditional Medicine:
- Historically, plants containing aristolochic acid were used in traditional Chinese medicine and other herbal remedies for conditions such as inflammation, arthritis, and wound healing. However, due to its toxicity, its use in medicine has been largely discontinued.
2. Research:
- Aristolochic acid丨313-67-7 is used in scientific research to study its mechanisms of toxicity and carcinogenicity. It serves as a model compound for understanding DNA damage and mutagenesis caused by nitrophenanthrene derivatives.
3. Toxicology Studies:
- It is used in toxicology to investigate the effects of nephrotoxic (kidney-damaging) and carcinogenic compounds, particularly in relation to "aristolochic acid nephropathy" (AAN) and its association with urothelial cancer.
Benefits
1. Research Tool:
- Aristolochic acid is valuable in research for studying DNA adduct formation, mutagenesis, and the development of cancers, particularly in the urinary tract.
2. Historical Significance:
- Its use in traditional medicine provides insight into the historical context of herbal remedies and the importance of evidence-based medicine.
Conclusion
Aristolochic acid丨313-67-7 is a highly toxic and carcinogenic compound with a controversial history of use in traditional medicine. While it has been valuable in research for understanding toxicity and carcinogenesis, its health risks far outweigh any potential benefits. Its use in medicine and consumer products is now banned or heavily regulated in most countries due to its association with kidney failure and cancer. Public awareness and strict regulatory measures are essential to prevent exposure and protect human health. Researchers and healthcare professionals must remain vigilant to ensure that aristolochic acid-containing products are not used or distributed.
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