7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
CAS 86393-33-1
CAS · 86393-33-1
Product Overview
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Characters | Off-white or Faintly Yellowish Powder |
|---|---|
| Purity | 99.0% min |
| Identification (HPLC) | Meet the required |
| Content (On the Anhydrous Basis) | 98.5% min |
| Loss on drying | 0.50% max |
| Total impurity | 1.0% max |
| Max. single impurity | 0.80% max |
Applications
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid is primarily utilized as a key intermediate in the synthesis of fluoroquinolone antibiotics. Its quinolone core structure, combined with halogen and cyclopropyl substitutions, provides the foundation for the development of potent antibacterial agents targeting DNA gyrase and topoisomerase IV. It is applied in medicinal chemistry research to generate new derivatives with enhanced spectrum activity against Gram-positive and Gram-negative bacteria. Additionally, it serves in structure-activity relationship (SAR) studies, allowing researchers to optimize pharmacokinetic properties, potency, and safety profiles in the design of novel antimicrobial drugs.
Benefits
The compound offers significant benefits due to its reactive quinolone scaffold and strategically placed substituents. The 6-fluoro and 7-chloro groups enhance antibacterial activity and cellular uptake, while the 1-cyclopropyl moiety improves potency and broad-spectrum efficacy. Its stability and well-defined stereochemistry enable reliable chemical transformations, facilitating high-yield synthesis of advanced fluoroquinolone derivatives. Furthermore, it allows for precise modifications at multiple positions on the quinolone ring, supporting the development of drugs with improved solubility, bioavailability, and reduced resistance potential. Overall, it accelerates the creation of high-value pharmaceutical candidates.
Conclusion
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid is an essential intermediate in modern antibacterial drug research. Its quinolone core, combined with halogen and cyclopropyl substitutions, provides a versatile platform for synthesizing potent fluoroquinolone antibiotics and exploring new derivatives. By enabling efficient synthesis and structural optimization, it plays a critical role in the development of next-generation antimicrobial agents with enhanced efficacy and safety profiles.
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