CAS · 651358-83-7
Product Overview
6-Bromopyridine-2-boronic acid pinacol ester is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white solid |
|---|---|
| Purity (by GC) | 98% min |
| HNMR | 95% min |
Applications
6-Bromopyridine-2-boronic acid pinacol ester is primarily used as an intermediate in pharmaceutical and fine chemical synthesis, especially in Suzuki–Miyaura cross-coupling reactions for constructing biaryl and heteroaryl structures. These reactions are essential in the synthesis of active pharmaceutical ingredients, agrochemical molecules, and advanced organic materials. In medicinal chemistry, it is frequently used to introduce pyridine moieties into drug candidates, supporting structure–activity relationship optimization for compounds targeting neurological, anti-inflammatory, and oncological pathways. The compound is also applied in the synthesis of functional organic materials, including organic semiconductors, liquid crystals, and optoelectronic components. In research laboratories, it serves as a versatile building block for heterocycle assembly and late-stage functionalization of complex molecules, enabling efficient diversification of molecular libraries during drug discovery programs.
Benefits
One of the key advantages of 6-Bromopyridine-2-boronic acid pinacol ester is its high reactivity and selectivity in palladium-catalyzed cross-coupling reactions. The boronic acid pinacol ester form improves chemical stability and simplifies storage and handling compared to free boronic acids, which are more prone to hydrolysis. The combination of a bromine leaving group and boronate nucleophilic coupling site provides dual synthetic functionality, allowing efficient multi-step synthetic strategies. The compound generally demonstrates good compatibility with common organic solvents and catalytic systems, supporting scalable industrial synthesis. From a manufacturing standpoint, boronic ester intermediates contribute to high reaction yields and reduced purification complexity, lowering production costs in large-scale chemical synthesis. Additionally, its heteroaromatic pyridine structure enhances molecular diversity potential in pharmaceutical research and materials chemistry.
Conclusion
6-Bromopyridine-2-boronic acid pinacol ester is an important synthetic intermediate widely used in cross-coupling chemistry, pharmaceutical development, and advanced material synthesis. Its high reactivity, improved stability as a boronic ester, and strong synthetic versatility make it a valuable building block in modern organic chemistry and industrial manufacturing. As demand for complex heteroaryl compounds continues to grow, this compound remains highly relevant in chemical innovation and drug discovery research.
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