6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzodimidazole
CAS 1231930-33-8
CAS · 1231930-33-8
Product Overview
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzodimidazole is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Purity | 98% min |
|---|---|
| Appearance | Off white powder |
| Single impurity | 0.5% max |
| Water content | 0.5% max |
Applications
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole is primarily used as a key intermediate in pharmaceutical and medicinal chemistry. Its functionalized benzimidazole core allows for selective derivatization at multiple positions, making it suitable for the synthesis of bioactive compounds, including enzyme inhibitors, receptor modulators, and CNS-active molecules. The bromine and fluorine substituents enable halogen-mediated cross-coupling reactions, facilitating the construction of complex heterocycles and drug candidates. It is also utilized in the preparation of advanced intermediates for agrochemicals, fine chemicals, and materials that require electron-rich or halogenated benzimidazole motifs.
Benefits
The compound offers several advantages due to its high functionalization and synthetic versatility. The combination of bromine, fluorine, and alkyl substituents allows for selective coupling, nucleophilic substitution, and other transformations, enabling efficient access to structurally diverse derivatives. The benzimidazole scaffold is chemically stable yet reactive at designated positions, supporting multi-step synthesis with minimal side reactions. Its halogenated structure improves reaction yields in cross-coupling and functionalization, while the isopropyl and methyl groups provide steric and electronic tuning to optimize downstream bioactivity. Overall, it is a reliable building block for generating complex molecules in research and industrial settings.
Conclusion
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole (CAS 1231930-33-8) is a versatile and valuable intermediate in pharmaceutical and chemical synthesis. Its combination of halogenation, alkyl substitution, and benzimidazole framework provides high synthetic flexibility, enabling efficient construction of bioactive compounds, heterocycles, and functionalized derivatives. This makes it an essential building block for modern medicinal chemistry and advanced chemical research.
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