CAS · 399-52-0
Product Overview
5-Fluoroindole is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to light brown (Solid) |
|---|---|
| Purity | 95% min |
Applications
5-Fluoroindole (CAS 399-52-0) is a fluorinated heterocyclic compound widely used in pharmaceutical and chemical research. It serves as a key building block in the synthesis of bioactive molecules, including anti-inflammatory, anticancer, and antimicrobial agents. Its indole core, combined with the electron-withdrawing fluorine atom, allows for selective functionalization and tuning of electronic properties, making it valuable in structure–activity relationship (SAR) studies. Additionally, 5-fluoroindole is used in the preparation of heterocyclic derivatives, fluorinated amino acids, and fluorescent probes, as well as in material science applications where the indole moiety contributes to optical and electronic properties.
Benefits
The benefits of 5-fluoroindole stem from its unique combination of the indole ring and fluorine substitution. The fluorine atom enhances chemical stability, metabolic resistance, and lipophilicity of derived compounds, improving drug-like properties. Its reactive positions on the indole ring allow for diverse chemical transformations, including electrophilic substitution, cross-coupling, and cyclization reactions, providing versatility in synthesis. The compound is chemically stable, soluble in common organic solvents, and compatible with a wide range of reaction conditions, facilitating multi-step synthetic processes. These properties make it an indispensable intermediate in medicinal chemistry and advanced organic synthesis.
Conclusion
5-Fluoroindole is a versatile fluorinated heterocyclic compound essential for pharmaceutical and chemical synthesis. Its combination of the indole core and fluorine substitution enables selective transformations, enhanced stability, and tunable bioactivity. By supporting efficient synthesis of bioactive molecules, fluorinated derivatives, and functional materials, 5-fluoroindole continues to be a critical building block in modern drug discovery and material science.
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