CAS · 63837-11-6
Product Overview
5-Bromo-2-methylbenzothiazole is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white powder |
|---|---|
| Purity | 97% min |
| Water | 1.0% max |
Applications
5-Bromo-2-methylbenzothiazole (CAS 63837-11-6) is an important heteroaromatic intermediate widely used in pharmaceutical, agrochemical, and materials chemistry. Its bromine-substituted benzothiazole framework allows it to participate in palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, enabling the construction of diverse functionalized derivatives. In medicinal chemistry, it serves as a building block for the synthesis of bioactive compounds, including kinase inhibitors, antimicrobial agents, and CNS-active molecules. Additionally, it is used in the development of fluorescent dyes, ligands, and advanced heterocyclic systems in research and fine chemical synthesis, where the bromine atom provides a convenient handle for selective substitution.
Benefits
The benefits of 5-Bromo-2-methylbenzothiazole stem from its reactive bromine atom and chemically stable benzothiazole ring. The bromine enables efficient derivatization through cross-coupling or nucleophilic substitution, while the methyl group offers steric and electronic tuning of reactivity and solubility. Its heterocyclic structure provides rigidity and favorable electronic properties, which are advantageous in drug design and material applications. The compound is stable, easy to handle, and compatible with various organic solvents and catalysts, making it highly practical for multi-step synthesis and large-scale production. These features allow rapid development of structural analogs with improved bioactivity or material performance.
Conclusion
5-Bromo-2-methylbenzothiazole is a versatile intermediate with broad applications in pharmaceuticals, agrochemicals, and advanced materials. Its combination of a reactive bromine substituent, methyl group, and benzothiazole core enables selective functionalization and efficient synthesis of bioactive or functional molecules. By supporting the creation of structurally diverse and high-value compounds, it remains a key reagent in modern chemical research and industrial applications.
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