5-Bromo-2-fluorobenzaldehyde

5-Bromo-2-fluorobenzaldehyde is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Pharmaceutical Intermediate

Frequently used as a building block in the synthesis of active pharmaceutical ingredients (APIs).

Especially useful in creating fluorinated aromatic compounds, often found in:

Anti-inflammatory drugs

Anticancer agents

Central nervous system (CNS) drugs

2. Agrochemical Synthesis

Used to produce intermediates for herbicides, fungicides, or insecticides.

The halogenated aromatic structure improves bioactivity and target specificity.

3. Organic Synthesis

Functions as a key precursor in forming:

Heterocycles (via condensation or cyclization)

Substituted benzoic acid derivatives

The aldehyde group offers flexibility for reactions such as:

Grignard reactions

Wittig reactions

Reductive aminations

4. Material Science

Can be utilized in functional material research, such as in the synthesis of fluorinated polymers or ligands for metal complexes, although this is less common.

Benefit
Explanation

Versatile Functional Groups
Aldehyde, fluorine, and bromine groups allow multiple synthetic pathways.

Enhances Bioactivity
Fluorine and bromine atoms often increase lipophilicity, metabolic stability, and binding affinity in drug and pesticide molecules.

Good Intermediate Stability
Allows for easy handling and storage in laboratory and manufacturing conditions.

Useful in Fine Chemicals
Ideal for diversifying aromatic rings in medicinal chemistry.

5-Bromo-2-fluorobenzaldehyde (CAS 93777-26-5) is a valuable synthetic intermediate, especially in pharmaceutical and agrochemical R&D. Its combination of bromine, fluorine, and aldehyde functionalities enables a wide range of chemical transformations, making it highly useful for target-oriented synthesis and complex molecule development.

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