CAS · 3680-69-1
Product Overview
4-Chloropyrrolo2,3-dpyrimidine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white to light yellow powder |
|---|---|
| Purity | 99.0% min |
| Total impurity | 1.0% max |
| Single impurity | 0.3% max |
| Loss on drying | 0.5% max |
Applications
4-Chloropyrrolo[2,3-d]pyrimidine is a key heterocyclic intermediate widely used in pharmaceutical and medicinal chemistry. Its chlorinated pyrrolopyrimidine core enables selective nucleophilic substitution, making it a versatile building block for the synthesis of nucleoside analogs, kinase inhibitors, and other bioactive heterocycles. It is frequently employed in the design of antiviral, anticancer, and anti-inflammatory agents due to its ability to introduce functionalized pyrrolopyrimidine scaffolds into target molecules. In addition, it serves as a precursor in the preparation of substituted derivatives for high-throughput screening libraries, allowing rapid exploration of structure-activity relationships (SAR) in drug discovery programs. Its chemical stability and reactivity make it suitable for both laboratory-scale synthesis and large-scale pharmaceutical development.
Benefits
The benefits of this compound arise from its structural versatility, reactivity, and compatibility with diverse synthetic transformations. The chloro group at the 4-position is highly reactive toward nucleophiles, facilitating efficient functionalization while maintaining the integrity of the heterocyclic core. This enables chemists to synthesize a wide variety of derivatives with precise substitution patterns, optimizing biological activity and pharmacokinetic properties. Its pyrrolopyrimidine scaffold contributes to strong binding affinity in many enzyme and receptor targets, supporting the development of potent and selective therapeutic agents. Additionally, its chemical stability under standard reaction conditions allows for reliable handling, storage, and reproducibility in synthesis, which is critical for both research and industrial applications. The compound's versatility also supports innovation in medicinal chemistry, enabling the rapid generation of novel analogs for drug discovery.
Conclusion
In summary, 4-Chloropyrrolo[2,3-d]pyrimidine is an essential intermediate in pharmaceutical chemistry and drug development. Its applications in synthesizing nucleoside analogs, kinase inhibitors, and other bioactive molecules, combined with benefits such as selective reactivity, structural versatility, and chemical stability, make it a valuable tool in medicinal chemistry. By enabling efficient and precise construction of heterocyclic derivatives, it continues to support innovation in drug discovery, therapeutic development, and chemical research.
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