CAS · 85030-56-4
Product Overview
3,6,9,12-Tetraoxatridecylamine is a high-purity polyethylene-glycol supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless or light yellow liquid |
|---|---|
| Purity(GC) | 95% min |
| 1H-NMR | Conforms to Structure |
| LC-MS | Conforms to Molecular Weight |
Applications
3,6,9,12-Tetraoxatridecylamine is a polyethylene glycol (PEG)-based amine widely used in pharmaceutical, biochemical, and materials science applications. Its primary amine functionality allows it to serve as a reactive building block for conjugation with carboxylic acids, activated esters, aldehydes, or other electrophiles, facilitating the synthesis of PEGylated drugs, peptides, proteins, and small molecules. The tetraethylene glycol chain enhances water solubility and flexibility, making it suitable for drug delivery, protein modification, and bioconjugation. Additionally, it is employed in polymer chemistry and materials science as a hydrophilic linker or spacer for surface functionalization, hydrogels, and nanoparticle modification.
Benefits
The benefits of 3,6,9,12-Tetraoxatridecylamine come from its combination of chemical reactivity, water solubility, and structural flexibility. The primary amine enables selective and efficient conjugation reactions under mild conditions, preserving the integrity of sensitive biomolecules. The tetraethylene glycol backbone enhances solubility, reduces aggregation, and provides a flexible spacer that minimizes steric hindrance in conjugated systems. It is chemically stable, compatible with both aqueous and organic solvents, and provides reproducible performance in laboratory and industrial syntheses. These features make it a valuable intermediate for creating PEGylated therapeutics, functionalized materials, and advanced chemical constructs.
Conclusion
3,6,9,12-Tetraoxatridecylamine is a versatile PEG-based amine used in bioconjugation, drug delivery, and materials functionalization. Its reactive amine group, combined with a hydrophilic tetraethylene glycol chain, enables efficient molecular modification, improved solubility, and enhanced flexibility. By supporting selective conjugation and structural versatility, it serves as an essential building block for pharmaceuticals, biomaterials, and advanced chemical applications.
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