CAS · 62351-47-7
Product Overview
3,5-Difluorophenylmagnesium bromide is a high-purity grignard-reagent supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Yellowish-brown to brown liquid |
|---|---|
| Purity (magnesium content) | 99% min |
| Molarity | 0.5 mol/L min |
| Solvent | THF |
Applications
3,5-Difluorophenylmagnesium bromide is a Grignard reagent widely used in organic synthesis and pharmaceutical research as a key organometallic intermediate. It is primarily employed for the introduction of the 3,5-difluorophenyl moiety into various carbonyl compounds, such as aldehydes, ketones, and esters, forming secondary and tertiary alcohols or other functionalized aromatic derivatives. This reagent is essential in the synthesis of bioactive molecules, fluorinated pharmaceuticals, agrochemicals, and fine chemicals where the difluorophenyl group modulates chemical, physical, and biological properties. It is also applied in medicinal chemistry for structure–activity relationship (SAR) studies and the construction of complex heterocyclic frameworks.
Benefits
The benefits of 3,5-Difluorophenylmagnesium bromide stem from its high reactivity, selectivity, and efficiency in forming C–C bonds. The difluorophenyl group contributes to improved metabolic stability, lipophilicity, and electronic properties in drug candidates, enhancing potency and pharmacokinetic profiles. As a Grignard reagent, it allows precise, predictable carbon–carbon bond formation under controlled conditions, facilitating the synthesis of diverse functionalized intermediates. Its compatibility with various solvents and reaction systems provides flexibility for multi-step syntheses, making it a valuable tool in both laboratory and industrial-scale organic synthesis.
Conclusion
3,5-Difluorophenylmagnesium bromide is a highly versatile Grignard reagent used for constructing fluorinated aromatic compounds in pharmaceuticals, agrochemicals, and fine chemical synthesis. Its combination of reactivity, selectivity, and the unique properties imparted by the difluorophenyl group makes it indispensable for modern medicinal chemistry and complex molecule synthesis. By enabling efficient and controlled C–C bond formation, it remains a crucial building block in advanced organic synthesis.
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