CAS · 202865-83-6
Product Overview
3-Fluoro-5-bromotoluene is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colorless or light yellow liquid |
|---|---|
| Purity (GC): | 99% min |
| Total impurity (GC): | 1.0% max |
| Maximum single impurity: | 0.5% max |
| Moisture: | 500 ppm max |
Applications
3-Fluoro-5-bromotoluene is a halogenated aromatic compound widely used as an intermediate in organic synthesis, pharmaceutical research, and material science. It is primarily employed in cross-coupling reactions, such as Suzuki, Stille, and Buchwald-Hartwig reactions, to construct biaryl and heteroaryl compounds, which are key scaffolds in drug discovery and agrochemical development. The bromine atom allows for selective functionalization, while the fluorine substituent imparts unique electronic properties, enhancing metabolic stability and biological activity of target molecules. Additionally, 3-fluoro-5-bromotoluene is utilized in the synthesis of specialty chemicals, ligands, and functional materials in research focused on aromatic substitution, heterocyclic chemistry, and fine chemical production.
Benefits
The compound offers significant advantages due to its dual halogen substitution pattern and reactivity. The bromine atom enables efficient cross-coupling reactions under mild conditions, while the fluorine atom modulates electronic characteristics, lipophilicity, and metabolic stability in derived compounds. Its crystalline and stable form allows for convenient handling, storage, and use in multi-step synthetic procedures. The combination of high reactivity, selectivity, and versatility makes it suitable for both small-scale laboratory synthesis and large-scale industrial production, supporting the efficient development of pharmaceuticals, agrochemicals, and advanced materials.
Conclusion
3-Fluoro-5-bromotoluene is a valuable halogenated intermediate in organic synthesis, pharmaceuticals, and materials research. Its reactive bromine atom and electronically tuned fluorine substituent make it indispensable for constructing bioactive molecules, heteroaryl compounds, and functional aromatic derivatives. The compound continues to support innovation in drug discovery, fine chemical production, and advanced material applications.
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