CAS · 128446-33-3
Product Overview
2-hydroxypropyl-α-cyclodextrin is a high-purity cyclodextrin-derivatives supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White or almost white powder, Odorless, slightly sweet; Freely soluble in water, soluble in methanol and ethanol, almost insoluble in acetone and trichloromethane. |
|---|---|
| pH: | 5.0 to 8.5 |
| Clarity of solution: | 2.5g/25ml water solution is clear |
| Water: | 10% max |
| Alpha-Cyclodextrin: | 1.5% max |
| Residue on ignition: | 0.2% max |
| Heavy metals: | 10 ppm max |
| Propylene glycol: | 0.5% max |
| Chloride: | 0.05% max |
| Hydroxypropoxyl content: | 22.3% to 36.1% |
| Total aerobic microbial count: | 1000 cfu/g max |
| Total combined moulds and yeasts count: | 100 cfu/g max |
| Escherichia coli: | Absence |
| Bacterial endotoxins test: | According to preparation needs |
Applications
1. Pharmaceutical Industry
Solubilizer and Carrier for Small Molecules: HPαCD enhances the aqueous solubility and stability of poorly water-soluble drugs like anesthetics, vitamins, and steroids.
Drug Delivery Systems: Used in oral, ophthalmic, and parenteral formulations for small active pharmaceutical ingredients (APIs).
Protein and Peptide Stabilization: Can protect labile biologics by preventing aggregation and degradation.
Controlled Release: Helps regulate the release rate of drugs by forming reversible inclusion complexes.
2. Food and Nutraceuticals
Flavor and Aroma Stabilizer: Protects and slowly releases volatile components in food products.
Encapsulation of Nutrients: Used to stabilize vitamins and fatty acids in supplements and functional foods.
Cholesterol Removal: Though less effective than β- or γ-CDs, it still demonstrates moderate activity in reducing cholesterol content in dairy.
3. Cosmetics and Personal Care
Fragrance Control: Encapsulates perfumes for prolonged scent release.
Active Stabilization: Preserves sensitive ingredients such as retinoids or essential oils.
Enhanced Skin Absorption: Can improve solubility and delivery of actives in topical formulations.
4. Agricultural and Industrial Uses
Pesticide Formulation: Improves solubility and delivery of hydrophobic agrochemicals.
Bioremediation: Forms complexes with environmental pollutants (e.g., phenols, hydrocarbons) for remediation.
Chromatography and Separation Science: Used in chiral separations due to its stereoselective binding ability.
Benefits
Feature
Benefit
High water solubility
Enables aqueous formulations of hydrophobic actives
Small internal cavity (~0.57 nm)
Ideal for small molecule encapsulation
Reduced crystallinity
Prevents precipitation in formulations
Low toxicity and non-irritating
Biocompatible and safe for ingestion and topical use
Biodegradable and eco-friendly
Environmentally sustainable choice
Thermal and chemical stability
Suitable for wide formulation and processing conditions
Conclusion
2-hydroxypropyl-α-cyclodextrin丨CAS 128446-33-3 is a highly water-soluble, safe, and effective cyclodextrin derivative designed for encapsulating and stabilizing small hydrophobic molecules. Its advantages-such as enhanced solubility, low toxicity, and cavity compatibility-make it suitable for pharmaceuticals, cosmetics, food additives, and environmental technologies. It is particularly valuable where β- or γ-cyclodextrins are too large or when high aqueous solubility is critical.
Previous
Next