2-Deoxy-D-glucose

2-Deoxy-D-glucose is a high-purity sugar-units supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Biomedical Research

Glycolysis Inhibitor:

2-DG competitively inhibits glucose metabolism by entering glycolysis but blocking subsequent steps, leading to depletion of cellular ATP. This property makes it an essential tool in studies involving:

Cancer metabolism

Cellular energy pathways

Hypoxia research

Radiotracer and Imaging:

Radiolabeled 2-DG analogs, such as 2-deoxy-2-[18F]fluoro-D-glucose (FDG), are widely used in positron emission tomography (PET) imaging to detect tumors and monitor metabolic activity, since many cancer cells exhibit increased glucose uptake.

2. Cancer Therapy

Metabolic Cancer Therapy:

Many tumors rely heavily on glycolysis (Warburg effect). 2-DG disrupts energy production in cancer cells, inducing:

Cell cycle arrest

Apoptosis (programmed cell death)

Enhanced sensitivity to chemotherapy and radiotherapy

Adjuvant in Treatment:

It is often studied in combination with other anticancer agents to improve efficacy and overcome drug resistance.

3. Antiviral and Infectious Disease Research

Viral Replication Inhibitor:

Since viruses often manipulate host glucose metabolism for replication, 2-DG has been investigated for:

Inhibiting replication of viruses like herpes simplex virus, influenza, and coronaviruses

Potential use in antiviral therapies by targeting metabolic pathways

4. Neurological Research

Neuroprotection and Brain Metabolism Studies:

2-DG helps study brain glucose utilization and neurodegenerative diseases by:

Mapping brain activity

Investigating energy metabolism in neuronal cells

5. Other Research Applications

Cellular Stress and Autophagy:

2-DG induces metabolic stress, useful for studying autophagy, unfolded protein response, and cell survival mechanisms.

Diabetes and Metabolic Disorder Models:

Employed in research models exploring insulin resistance and glucose metabolism disorders.

✅ Specific Glycolytic Inhibition

Targets glycolysis selectively, allowing detailed study and modulation of energy metabolism in cells.

✅ Cancer-Targeted Therapy Potential

Exploits cancer cells' reliance on glycolysis, offering a therapeutic strategy with relatively low toxicity to normal cells.

✅ Non-Invasive Imaging

Radiolabeled derivatives facilitate tumor imaging and diagnosis without invasive biopsies.

✅ Research Versatility

Useful across multiple disciplines: oncology, virology, neurology, and metabolism.

✅ Potential Combination Therapy Enhancer

Increases effectiveness of radiation and chemotherapy by weakening tumor metabolism.

2-Deoxy-D-glucose (2-DG) is a glucose analog that serves as a critical glycolytic inhibitor, widely applied in cancer research, metabolic studies, and diagnostic imaging. Its unique mechanism of disrupting cellular energy metabolism makes it a valuable tool in understanding and potentially treating diseases with altered glucose utilization, especially cancer. While its clinical applications are still evolving, 2-DG remains a cornerstone molecule in biomedical research.

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