CAS · 20885-12-5
Product Overview
2-Chloro-6-fluoropyridine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White solid |
|---|---|
| Purity (GC): | 99% min |
| Water: | 0.5% max |
| Single impurity: | 0.5% max |
Applications
2-Chloro-6-fluoropyridine is widely used as a synthetic intermediate in pharmaceutical research for the preparation of active pharmaceutical ingredients (APIs) and heterocyclic compounds. Its halogen substituents make it suitable for nucleophilic aromatic substitution and cross-coupling reactions such as Suzuki, Stille, or Buchwald–Hartwig couplings, enabling the construction of pyridine-based drug candidates and ligands. It is often incorporated into CNS-active compounds, kinase inhibitors, and anti-inflammatory agents due to the pyridine scaffold's compatibility with biological targets. In agrochemical synthesis, it serves as a key precursor for herbicides, insecticides, and fungicides, offering favorable lipophilicity and metabolic stability. It is also employed in material science, where fluorinated heterocycles contribute to the development of high-performance polymers, liquid crystals, and electronic materials.
Benefits
The benefits of 2-Chloro-6-fluoropyridine include its high reactivity, structural tunability, and chemical robustness. The presence of both chlorine and fluorine atoms provides versatile sites for selective substitution, enabling efficient derivatization under controlled conditions. The fluorine atom enhances lipophilicity, metabolic stability, and electronic properties, which are crucial for improving pharmacokinetic performance and chemical durability. Its stability under ambient conditions and solubility in common organic solvents facilitate easy handling and storage. Moreover, the compound's compatibility with various synthetic methods makes it suitable for both laboratory-scale research and industrial-scale production.
Conclusion
In summary, 2-Chloro-6-fluoropyridine is an important halogenated pyridine derivative widely used in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Its unique dual-halogen substitution pattern offers excellent versatility for chemical transformations and molecular design. With its high stability, reactivity, and favorable electronic characteristics, it serves as a key building block in the development of high-value compounds across multiple scientific and industrial disciplines.
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