2-Chloro-1,3-dimethylimidazolidinium chloride

2-Chloro-1,3-dimethylimidazolidinium chloride is a high-purity lithium-chemicals supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Coupling Reagent in Peptide Synthesis

Used as an activating agent for carboxylic acids in peptide bond formation.

Often employed in solid-phase peptide synthesis (SPPS) and solution-phase synthesis.

Serves as a milder alternative to traditional carbodiimide-based coupling reagents.

2. Reagent for Amidation and Esterification

Promotes amide and ester formation with high yields and low epimerization risk.

Effective for synthesizing pharmaceutical intermediates, bioactive compounds, and modified polymers.

3. Synthesis of Heterocyclic Compounds

Plays a role in cyclization reactions to produce diverse imidazolidinone derivatives.

Useful in medicinal chemistry for building complex structures.

4. Activator in Organic Reactions

Acts as a chlorinating and condensing agent.

Often used with bases or additives to promote selective transformations.

✅ High Coupling Efficiency

Facilitates rapid and clean peptide bond formation without excessive byproducts.

✅ Mild Reaction Conditions

Allows reactions to proceed under ambient to moderate temperatures, preserving sensitive functional groups.

✅ Low Racemization Risk

Provides stereochemical stability, making it ideal for chiral molecule synthesis.

✅ Compatible with Diverse Substrates

Suitable for coupling amino acids, peptides, nucleosides, and complex natural products.

✅ Scalable and Reproducible

Well-documented use in laboratory and industrial-scale synthesis.

2-Chloro-1,3-dimethylimidazolidinium chloride (CAS 37091-73-9) is a powerful and selective reagent for coupling reactions, widely employed in peptide synthesis, medicinal chemistry, and organic synthesis. Its high efficiency, low racemization, and ease of handling make it an essential tool for modern synthetic chemists.

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