CAS · 446-09-3
Product Overview
2-Bromo-5-fluoronitrobenzene is a high-purity fluorine supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to light yellow solid |
|---|---|
| Purity | 98% min |
| Water | 0.5% max |
Applications
2-Bromo-5-fluoronitrobenzene is widely used as an intermediate for the synthesis of substituted aromatic compounds, heterocycles, and bioactive molecules. In pharmaceutical chemistry, it serves as a building block for preparing anticancer, antiviral, and anti-inflammatory agents, particularly through nucleophilic aromatic substitution or cross-coupling reactions (e.g., Suzuki, Heck, and Buchwald–Hartwig couplings). The nitro group can be selectively reduced to an amino group, enabling further derivatization and incorporation into complex molecular scaffolds. In agrochemical research, it is used to synthesize novel herbicides, fungicides, and insecticides with improved activity. Additionally, it is applied in materials science for the preparation of functional dyes, polymers, and specialty chemicals where halogenated aromatics provide electronic or structural benefits.
Benefits
The main benefits of 2-Bromo-5-fluoronitrobenzene include its multifunctional reactivity and compatibility with various organic transformations. The bromine atom allows efficient cross-coupling reactions, the fluorine atom can modulate electronic properties and metabolic stability in drug candidates, and the nitro group offers a handle for reduction and functionalization. Its chemical stability under standard storage conditions ensures reliable handling and reproducibility in synthetic processes. The combination of halogen and nitro functionality enables selective transformations, making it a powerful intermediate for constructing complex molecules with tailored properties.
Conclusion
2-Bromo-5-fluoronitrobenzene is a versatile halogenated aromatic intermediate extensively used in pharmaceuticals, agrochemicals, and specialty chemical synthesis. Its combination of bromine, fluorine, and nitro substituents allows precise chemical transformations, facilitating the construction of bioactive molecules, heterocycles, and functional materials. As the demand for multifunctional and halogenated intermediates grows, this compound remains an important building block in modern organic synthesis and chemical research.
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