2-Amino-4,6-dihydroxypyrimidine

2-Amino-4,6-dihydroxypyrimidine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Pharmaceutical Intermediate

Used in the synthesis of antiviral, anticancer, and antimetabolite drugs.

A core scaffold in:

Pyrimidine-based pharmaceuticals

Nucleoside analogues

Antifolates (inhibitors of folic acid pathways)

Examples include its use in the development of:

Allopurinol analogs for gout

Pyrimidine nucleoside drugs like zidovudine or other antiretrovirals

2. Intermediate for Agrochemicals

Precursor in the synthesis of herbicides, fungicides, and plant growth regulators.

Pyrimidine derivatives are essential for crop protection chemicals due to their biological activity.

3. Building Block for Heterocyclic Chemistry

The molecule serves as a key heterocyclic intermediate in organic synthesis.

Useful for the preparation of:

Polycyclic systems

Bioisosteres in medicinal chemistry

Functionalized pyrimidines for biochemical studies

4. Research in Nucleic Acid Chemistry

Due to structural similarity with cytosine and uracil, it is used in:

Studies of nucleic acid base pairing

Mimicry of DNA/RNA behavior

Enzyme-substrate interaction modeling

5. Coordination Chemistry and Material Science

The amino and hydroxyl groups offer multiple coordination sites, enabling use as:

Ligand in metal complexes

Chelating agent in analytical or catalytic chemistry

✅ Versatile Functional Groups

The amino and hydroxyl groups enhance reactivity, allowing:

Easy derivatization

Participation in hydrogen bonding

Nucleophilic substitution and ring transformations

✅ Biological Compatibility

The pyrimidine ring is a biologically privileged structure, found in DNA/RNA.

Offers good bioavailability and metabolic stability when incorporated into pharmaceuticals.

✅ Foundation for Drug Discovery

A valuable lead scaffold in the development of bioactive molecules.

Easily modified to enhance target specificity, solubility, or pharmacokinetics.

✅ Low Toxicity and Environmental Safety

As a relatively simple and non-halogenated molecule, it tends to have lower environmental persistence and biocompatibility, making it suitable for further modification in pharmaceutical and agricultural contexts.

2-Amino-4,6-dihydroxypyrimidine (CAS 56-09-7) is a key intermediate in pharmaceutical and agrochemical synthesis. With a structure closely related to natural nucleic acid bases, it serves as a foundation for developing a wide range of bioactive molecules, including antivirals, anticancer agents, and plant protection compounds. Its chemical flexibility, biological relevance, and synthetic utility make it a valuable compound in medicinal chemistry, nucleic acid research, and heterocyclic compound design.

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