(1R,2S)-2-fluorocyclopropane-1-carboxylic acid

(1R,2S)-2-fluorocyclopropane-1-carboxylic acid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

(1R,2S)-2-Fluorocyclopropane-1-carboxylic acid is a chiral fluorinated cyclopropane derivative widely used in pharmaceutical and medicinal chemistry as a building block for the synthesis of bioactive molecules. Its rigid cyclopropane ring, combined with the fluorine substituent, is often employed to enhance metabolic stability, improve binding affinity, and modulate physicochemical properties of target compounds. The carboxylic acid functionality allows for versatile reactions, such as amidation, esterification, and peptide coupling, making it suitable for the construction of small-molecule drugs, enzyme inhibitors, and peptide mimetics. It is particularly valuable in the design of antiviral, anticancer, and CNS-active agents, where fluorinated cyclopropane motifs can improve selectivity and pharmacokinetic profiles. Additionally, it is used in research for the synthesis of fluorinated analogs to explore structure–activity relationships (SAR) and optimize drug candidates.

The benefits of (1R,2S)-2-fluorocyclopropane-1-carboxylic acid stem from its stereochemical purity, chemical stability, and functional versatility. The rigid cyclopropane ring imparts conformational constraint, which can enhance receptor selectivity and reduce metabolic degradation. The fluorine atom influences electronic properties, lipophilicity, and hydrogen bonding interactions, improving bioavailability and target engagement. The carboxylic acid group allows for efficient derivatization into esters, amides, and other functional derivatives without affecting the stereochemistry. Its well-defined chiral configuration ensures reproducibility and high yield in multi-step synthesis, supporting both laboratory-scale research and industrial drug development.

(1R,2S)-2-Fluorocyclopropane-1-carboxylic acid is a high-value chiral intermediate for pharmaceutical and medicinal chemistry applications. Its combination of cyclopropane rigidity, fluorine substitution, and carboxylic acid functionality enables the design of bioactive molecules with enhanced stability, selectivity, and pharmacokinetic properties. By facilitating precise molecular modifications and supporting structure–activity relationship studies, it continues to be an essential building block in the development of innovative therapeutic agents.

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