1,3-Dibromo-5-iodobenzene

1,3-Dibromo-5-iodobenzene is a high-purity oled-materials supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Cross-Coupling Reactions

● A prime precursor in Suzuki, Stille, Heck, and Sonogashira couplings.

● The presence of multiple halogens (Br and I) allows selective functionalization of different positions under specific conditions:
The iodo group is more reactive and often used first in coupling.
Remaining bromo groups can be selectively reacted afterward, enabling stepwise construction of complex molecules.

2. Pharmaceutical and Medicinal Chemistry

● Acts as a synthetic intermediate for developing drug candidates.

● Enables the construction of tri-substituted aromatic scaffolds that mimic bioactive natural products or synthetic pharmaceuticals.

3. Organic Electronics and Materials Science

● Used in the synthesis of π-conjugated molecules and functionalized polymers:
OLEDs (Organic Light Emitting Diodes)
OFETs (Organic Field Effect Transistors)
Solar cell components

● Offers halogen-rich frameworks suitable for fine-tuning electronic properties.

4. Agrochemical Development

● A building block in the design of novel herbicides, insecticides, and fungicides with enhanced selectivity and stability.

5. Radiolabeling and Isotope Chemistry

● The iodine atom can be replaced with isotopically labeled iodine (e.g., I-125 or I-131), allowing its use in radioactive tagging for diagnostics or tracer studies.

1. Versatile Functionalization

● Halogens serve as leaving groups, enabling a wide range of nucleophilic substitutions and palladium-catalyzed couplings.

● The molecule provides orthogonal reactivity, allowing sequential reactions at iodine and bromine sites.

2. Efficient Scaffold for Diversification

● The 1,3,5-substitution pattern creates opportunities for producing highly branched or symmetric molecules, important in materials science and medicinal chemistry.

3. Enhanced Selectivity

● Due to the difference in reactivity between iodine and bromine atoms, it allows controlled stepwise synthesis of multifunctional compounds.

4. Stability and Shelf Life

● Solid at room temperature and relatively stable under standard storage conditions, making it suitable for long-term use in research labs.

1,3-Dibromo-5-iodobenzene丨CAS 19752-57-9 is a strategic intermediate in the synthesis of complex organic molecules, offering selective reactivity and broad compatibility with modern coupling techniques. Its application in drug discovery, materials science, and agrochemical innovation highlights its importance in both academic and industrial research settings.

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