CAS · 137081-41-5
Product Overview
1-Fluoro-cyclopropanecarboxylic acid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to Brown Solid |
|---|---|
| Purity: | 98% min |
| 1H NMR: | Conforms to structure |
| Water: | 1.0% max |
Applications
1. Pharmaceutical Intermediates
Used as a key building block in the synthesis of various pharmaceutical compounds.
Especially important in the design of bioactive molecules where fluorine enhances metabolic stability and bioavailability.
May be used in the preparation of fluorinated drug candidates, particularly in antiviral, anticancer, and CNS-active compounds.
2. Agrochemical Synthesis
Serves as a precursor or intermediate in the development of herbicides, insecticides, or fungicides that incorporate fluorinated cyclopropane motifs.
Fluorination can improve lipophilicity, target selectivity, and resistance to degradation in plant protection agents.
3. Synthetic Organic Chemistry
Employed in ring-opening reactions, esterification, and amide formation for building complex molecules.
Its strained ring and fluorine substitution provide reactivity leverage in organofluorine chemistry.
4. Development of Specialty Fluorochemicals
Can be used in the synthesis of fluorinated monomers and functional materials for use in advanced polymers and electronic materials.
Benefits
✅ Fluorine Functionality
The fluorine atom increases:
Lipophilicity
Chemical and metabolic stability
Binding affinity in biological targets
✅ Cyclopropane Ring Strain
The cyclopropane ring:
Introduces conformational rigidity
Enhances receptor selectivity and target engagement
Facilitates stereochemical control in complex molecule synthesis
✅ Versatile Reactivity
The carboxylic acid group enables:
Ester and amide bond formation
Compatibility with peptide coupling reactions
Utility in fragment-based drug design (FBDD)
✅ Compact Structure
Ideal for fragment libraries and lead optimization where small, highly functionalized molecules are desired.
Conclusion
1-Fluoro-cyclopropanecarboxylic acid (CAS 137081-41-5) is a valuable intermediate in medicinal and agrochemical research, prized for its unique combination of fluorine chemistry, strained ring structure, and synthetic flexibility. It is especially useful for crafting advanced molecules with improved pharmacokinetics and biological activity.
Previous
4-Bromo-3-fluorobenzaldehyde丨CAS 133059-43-5
Next