CAS · 20469-65-2
Product Overview
1-Bromo-3,5-dimethoxybenzene is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Light yellow to white crystals |
|---|---|
| Purity | 99% min |
| Water | 0.5% max |
| Melting point | 62–66 °C |
Applications
1. Intermediate in Organic Synthesis
● 1-Bromo-3,5-dimethoxybenzene丨CAS 20469-65-2 serves as a key building block in the synthesis of pharmaceuticals, agrochemicals, and functional materials.
● Its electron-donating methoxy groups and electron-withdrawing bromine allow for selective reactivity in:
Cross-coupling reactions (e.g., Suzuki, Stille, Heck)
Nucleophilic aromatic substitution
Halogen-lithium exchange
2. Pharmaceutical Research
● Used in the design and synthesis of bioactive molecules such as:
CNS drugs (e.g., serotonin or dopamine analogs)
Anti-inflammatory and antimicrobial agents
● Enables fine-tuning of aromatic substitution patterns for medicinal chemistry optimization (e.g., modifying pharmacophores)
3. Material Science and Functional Dyes
● A useful intermediate in creating conjugated organic materials for:
OLEDs
Conductive polymers
Dyes and pigments
● The bromine functionality supports aryl coupling to extend π-conjugation.
4. Agrochemical Development
● Employed in the synthesis of fungicides, herbicides, and plant growth regulators.
● The presence of bromine allows easy modification for structure–activity relationship (SAR) studies.
Benefits
1. Versatile Reactivity
● The bromine atom allows for Pd-catalyzed cross-coupling reactions, making it an excellent starting material for synthesizing complex aromatic compounds.
● Methoxy groups stabilize intermediates in electrophilic substitution, enhancing reaction control.
2. Electron-Rich Aromatic Ring
● The 3,5-dimethoxy substitution pattern activates the ring toward selective substitution and facilitates regioselective synthesis.
3. Useful in Fine Chemical Synthesis
● Well-suited for laboratories and industries focused on custom synthesis, target molecule discovery, and derivatization of aromatic frameworks.
Conclusion
1-Bromo-3,5-dimethoxybenzene丨CAS 20469-65-2 is a valuable synthetic intermediate in pharmaceutical, agrochemical, and material science applications. Its functional groups enable selective reactivity, making it particularly useful for aryl coupling and ring substitution reactions. With broad utility in fine chemical synthesis and molecular design, it supports both research innovation and industrial production.
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