CAS · 2252-63-3
Product Overview
1-(4-Fluorophenyl)piperazine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colorless to light yellow liquid or solid |
|---|---|
| Purity: | 98% min |
| Water: | 1% max |
Applications
1. Pharmaceutical Research
Drug Intermediate:
Widely used as a building block for synthesizing various pharmaceutical compounds, particularly those targeting the central nervous system (CNS).
Psychoactive Agents:
The compound and its derivatives serve as scaffolds in the development of drugs affecting serotonin receptors (5-HT), dopamine receptors, and other neurotransmitter systems.
Antidepressants and Antipsychotics:
Used in the synthesis of molecules with potential antidepressant, anxiolytic, or antipsychotic activities.
2. Chemical Biology
Receptor Ligand Development:
Used to design and study ligands for serotonin and dopamine receptors to better understand neurological processes.
Neuropharmacology Studies:
Applied in research on receptor binding, transport mechanisms, and neurotransmitter regulation.
3. Synthetic Chemistry
Versatile Building Block:
The piperazine nitrogen and the fluorophenyl substituent enable derivatization for creating diverse chemical libraries in drug discovery.
Benefits
Structural Versatility:
The presence of the fluorine atom modifies electronic properties, often improving metabolic stability and receptor binding affinity of derivatives.
CNS Activity:
Its structure is foundational for many CNS-active compounds, making it highly valuable in neuropharmacological research.
Synthetic Accessibility:
Commercially available and amenable to a variety of chemical transformations.
Conclusion
1-(4-Fluorophenyl)piperazine (CAS 2252-63-3) is a critical intermediate in medicinal chemistry, especially for the development of CNS-active agents. Its unique combination of a piperazine core with a fluorophenyl substituent offers advantageous properties for drug design, including enhanced receptor interaction and metabolic profile. This compound continues to be a valuable scaffold in neuropharmacological research and pharmaceutical synthesis.
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