CAS · 60811-18-9
Product Overview
4-Bromo-1-chloro-2-fluorobenzene is a high-purity fluorine supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Clear or light yellow liquid |
|---|---|
| Water | 0.3% max |
| Content | 99.5% min |
Applications
1. Pharmaceutical Intermediate
● Used as a building block in the synthesis of active pharmaceutical ingredients (APIs).
● Facilitates the development of fluorinated and halogenated aromatic scaffolds, which are common in antiviral, oncology, and CNS drugs.
● Valuable in the design of compounds with enhanced metabolic stability and membrane permeability.
2. Agrochemical Synthesis
● Intermediate in the preparation of herbicides, fungicides, and insecticides.
● Halogenated aromatic compounds are key structural motifs in crop protection agents, offering improved bioactivity and environmental persistence.
3. Material Science and Specialty Polymers
● 4-Bromo-1-chloro-2-fluorobenzene丨CAS 60811-18-9 is used in the synthesis of fluorinated monomers and functional materials, especially in liquid crystals, OLEDs, and high-performance plastics.
● Halogenated aromatics improve thermal stability, chemical resistance, and electronic properties of polymers.
4. Organic Synthesis Reagent
● Useful in cross-coupling reactions (e.g., Suzuki, Stille, Negishi) as a halogenated aromatic partner:
Bromine offers high reactivity.
Fluorine can modulate electron density and physicochemical properties.
● Enables the introduction of multiple halogen atoms into target molecules, aiding in SAR (Structure–Activity Relationship) studies.
Benefits
1. Versatile Halogenated Substrate
● The presence of three different halogens (Br, Cl, F) provides regioselective reactivity, allowing for:
Sequential substitution or functionalization
Fine-tuning of chemical and biological properties
2. Enhanced Molecular Properties
● Fluorine improves:
Lipophilicity
Metabolic stability
Binding affinity in bioactive compounds
● Bromine and chlorine facilitate selective C–C bond formation in synthesis pipelines.
3. Synthetic Accessibility
● Commercially available and compatible with a wide range of synthetic methodologies, from aromatic substitution to metal-catalyzed coupling.
● Serves as a cost-effective starting point for high-value compound libraries.
Conclusion
4-Bromo-1-chloro-2-fluorobenzene丨CAS 60811-18-9 is a strategically halogenated aromatic compound offering excellent reactivity and versatility across multiple industries. Whether used as a pharmaceutical or agrochemical intermediate, a material science precursor, or a reagent in organic synthesis, it provides chemists with a highly functional building block for advanced chemical and molecular engineering.
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