CAS · 4235-95-4
Product Overview
Dierucoyl phosphatidylcholine is a high-purity biochemical-reagents supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Off white to white waxy solid |
|---|---|
| Purity (HPLC): | 99% min |
| Storage: | Protect from light and store in a dry place (≤ -20°C) |
Applications
Dierucoyl phosphatidylcholine (DEPC) is a synthetic phospholipid widely utilized in pharmaceutical formulation, biochemistry, and membrane research. Structurally composed of a phosphatidylcholine backbone esterified with two erucic acid (C22:1) chains, it serves as a model lipid for studying membrane dynamics and lipid-lipid interactions due to its long unsaturated hydrocarbon tails. In the pharmaceutical industry, DEPC is frequently employed in liposome and lipid nanoparticle formulations, where it acts as a stabilizing component that enhances bilayer rigidity and controls drug release rates. It is also applied in targeted drug delivery systems, especially for hydrophobic and amphiphilic molecules. In biochemical research, DEPC is used to mimic biological membranes for protein-lipid interaction studies, receptor reconstitution, and ion channel assays. Its unique physicochemical characteristics make it valuable in the design of biomimetic systems and lipid-based therapeutic carriers.
Benefits
Dierucoyl phosphatidylcholine offers multiple functional and formulation advantages. The long monounsaturated erucoyl chains provide high thermal stability and reduced membrane permeability, contributing to longer circulation times for liposomal or nanoparticle-based drug carriers. These properties improve encapsulation efficiency and controlled release of active pharmaceutical ingredients, resulting in enhanced therapeutic efficacy and bioavailability. Additionally, DEPC's biocompatibility and non-toxic nature make it suitable for in vivo applications, ensuring safety and minimal immune response. Its defined molecular structure and predictable behavior also facilitate reproducible results in biophysical and pharmacological research. In membrane modeling, DEPC enables precise control of lipid phase behavior, aiding the understanding of membrane fluidity, curvature, and protein incorporation under physiological conditions.
Conclusion
Dierucoyl phosphatidylcholine is an advanced functional lipid with critical roles in pharmaceutical delivery systems, lipid membrane studies, and biotechnological innovation. Its combination of structural stability, biocompatibility, and versatility supports its use in both applied and fundamental research. As lipid-based therapeutics and nanocarriers continue to evolve, DEPC remains an indispensable material for developing high-performance drug delivery platforms and exploring the complex behavior of biological membranes.
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