CAS · 1067-74-9
Product Overview
Methyl diethylphosphonoacetate is a high-purity catalysts-auxiliary-agent supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless liquid |
|---|---|
| Purity (GC) | 98% min |
| Refractive index n20/D | 1.431–1.435 |
| Density (20 °C) | 1.159–1.164 |
| Proton NMR spectrum | Conforms to structure |
Applications
Methyl diethylphosphonoacetate is widely used as a versatile reagent in organic synthesis, particularly in C–C bond-forming reactions. It is a key component in the Horner–Wadsworth–Emmons (HWE) reaction, enabling the synthesis of alkenes with excellent stereoselectivity. The compound is frequently applied in the preparation of pharmaceuticals, agrochemicals, and fine chemicals, where its phosphonate ester structure allows efficient formation of functionalized olefins and intermediates. It is also used in the synthesis of bioactive molecules, natural product analogs, and heterocycles. In materials and polymer chemistry, it serves as a precursor for incorporating phosphonate groups, contributing to flame retardancy and enhanced material performance. The compound's compatibility with various bases and solvents makes it a valued reagent in research laboratories developing advanced synthetic methodologies.
Benefits
The benefits of methyl diethylphosphonoacetate include its predictable reactivity, stability, and suitability for stereoselective transformations. It enables the formation of E-selective alkenes under mild conditions, improving efficiency and reducing byproduct formation. Its phosphonate ester group provides excellent control in carbonyl condensation reactions, making it a reliable tool for constructing complex molecular architectures. The reagent is relatively easy to handle, stores well, and exhibits compatibility with a wide range of substrates. These characteristics make it valuable for both routine synthetic work and advanced research applications, supporting high yields and reproducible outcomes.
Conclusion
Methyl diethylphosphonoacetate is a highly useful reagent employed in olefination reactions, pharmaceutical synthesis, and materials development. Its stability, predictable reactivity, and versatility in forming carbon–carbon bonds make it essential in creating complex molecules and functional materials. These properties ensure its continued importance in organic synthesis and applied chemical research.
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