CAS · 87413-09-0
Product Overview
Dess-Martin periodinane is a high-purity catalysts-auxiliary-agent supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White powder or crystalline particles |
|---|---|
| Assay (by titration) | 98% min |
| Dichloromethane solution | Slightly cloudy or clear solution |
| Identify | HNMR conforms |
Applications
Dess-Martin periodinane is a highly effective oxidizing agent widely used in organic synthesis, medicinal chemistry, and fine chemical production. It is primarily applied for the selective oxidation of primary alcohols to aldehydes and secondary alcohols to ketones under mild conditions, avoiding over-oxidation to carboxylic acids. In pharmaceutical synthesis, it is used for constructing sensitive intermediates in multi-step drug development pathways, including heterocycles, steroid derivatives, and complex natural products. The reagent is also employed in academic and industrial research for total synthesis projects, stereoselective transformations, and the preparation of oxidation-sensitive compounds. Its compatibility with a wide range of solvents and functional groups makes it a versatile choice for complex organic reactions, including late-stage oxidation in target molecule synthesis.
Benefits
The benefits of Dess-Martin periodinane stem from its high selectivity, mild reaction conditions, and operational convenience. It enables rapid oxidation at ambient temperature without the need for strong acids, bases, or high temperatures, reducing side reactions and decomposition of sensitive substrates. The reagent shows excellent chemoselectivity, allowing oxidation of alcohols in the presence of alkenes, ethers, and other functional groups. It is easy to handle in the laboratory, soluble in common organic solvents, and provides high yields with minimal work-up requirements. Compared to traditional oxidants like chromium-based reagents, Dess-Martin periodinane is more environmentally friendly and safer to use, supporting greener and more sustainable synthetic processes.
Conclusion
Dess-Martin periodinane is a versatile and reliable oxidizing reagent for organic synthesis, particularly in the selective conversion of alcohols to aldehydes and ketones. Its mild reaction conditions, high chemoselectivity, and compatibility with sensitive functional groups make it an indispensable tool in pharmaceutical, academic, and industrial chemistry applications. By enabling efficient, high-yield, and controlled oxidations, Dess-Martin periodinane continues to play a crucial role in modern organic synthesis and complex molecule construction.
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